Electric Literature of 133803-81-3, Adding some certain compound to certain chemical reactions, such as: 133803-81-3, name is tert-Butyl 3-(2-(2-hydroxyethoxy)ethoxy)propanoate,molecular formula is C11H22O5, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 133803-81-3.
ferf-Butyl 3 (2 (2- hydroxyethoxy)ethoxy)propanoate (8.6 g, 37 mmol) was added to a suspension of Dess- Martin periodinane (DMP, 18.8 g, 44 mmol) and pyridine (7.0 g, 88 mmol) in DCM (150 mL) at 0C. The resulting mixture was stirred at room temperature for 16 hours, then filtered, washed with DCM (3 x 50 mL). The filtrate and washings were combined and washed with saturated NaHC03 solution and brine, dried over anhydrous sodium sulfate, filtered and concentrated. The residue was purified by silica chromatography (hexane:EtOAc = 10: 1 to 3: 1) to give the title compound (4.1 g, 48%) as a yellow oil. 1H NMR (400 MHz, CDC13): delta 9.76 (s, 1H), 4.16 (s, 2H), 3.50-3.80 (m, 6H), 2.53(t, 2H), 1.46 (s, 9H).
According to the analysis of related databases, 133803-81-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; CORNELL UNIVERSITY; DANA-FARBER CANCER INSTITUTE, INC.; CHILDREN’S MEDICAL CENTER CORPORATION; MELNICK, Ari, M.; GABAS, Lorena, Fontan; US, Ilkay; CASALENA, Gabriella; GRAY, Nathanael, S.; SCOTT, David, A.; HATCHER, John; DU, Guangyan; WU, Hao; QIAO, Qi; (157 pag.)WO2018/85247; (2018); A1;,
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