A new synthetic route of 10160-28-8

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,10160-28-8, its application will become more common.

Application of 10160-28-8 ,Some common heterocyclic compound, 10160-28-8, molecular formula is C9H16O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a mixture of non-8-yn-1-ol (5.00 g, 35.6 mmol, CAS10160-28-8) and TEA (10.8 g, 106 mmol, 14.8 mL) in DCM (100 mL) was added MsCl (6.13 g, 53.4 mmol, 4.14 mL). The reaction mixture was stirred at 25 C. for 2 hours. On completion, the reaction mixture was concentrated in vacuo. The residue was diluted with water (10 mL) and extracted with DCM (3×10 mL). The combined organic layers was dried over Na2SO4, filtered and concentrated in vacuo to give the title compound (7.70 g, 98% yield) as light yellow oil. 1H NMR (400 MHz, CDCl3) delta 4.23 (t, J=6.4 Hz, 2H), 3.01 (s, 3H), 2.22-2.18 (m, 2H), 1.95 (t, J=2.4 Hz, 1H), 1.80-1.73 (m, 2H), 1.58-1.50 (m, 2H), 1.47-1.36 (m, 6H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,10160-28-8, its application will become more common.

Reference:
Patent; Kymera Therapeutics, Inc.; Mainolfi, Nello; Ji, Nan; Kluge, Arthur F.; Weiss, Matthew M.; Zhang, Yi; (1443 pag.)US2019/192668; (2019); A1;,
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