Application of 1805-32-9 ,Some common heterocyclic compound, 1805-32-9, molecular formula is C7H6Cl2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
General procedure: To a solution of alcohol (1mmol) in 2mL of toluene was added GO (0.3g). The resulting mixture was sonicated in an Elmasonic P ultrasonic cleaning unit (ultrasonic bath) with a frequency of 37kHz and 100% output power at 80C for the time indicated in Table 4. Then Oxone (1mmol) and 2mL of an alcoholic solvent was added in the reaction medium and the resulting mixture was irradiated for the time indicated in Table 4. The mixture was filtered through a sintered funnel and evaporated under reduced pressure, and extracted with ethyl acetate. The organic layer was dried over Na2SO4, filtered and evaporated under reduced pressure. Purification was achieved by column chromatography using n-hexane/EtOAc: 100/3 as eluent. The spectroscopic data of the obtained esters were compared with authentic samples [5,40,42,43]. Spectroscopic data for methyl 3,4-dichlorobenzoate (entry 9, Table 4): Pale yellow, M.P. 44.7C; IR (KBr) nu=3089, 3022, 2958, 1729, 1589, 1435, 1378, 1301, 1110, 757cm-1; 1H NMR (300MHz, CDCl3) delta=3.94 (s, 3H, CH3), 7.53 (d, J=8.3Hz, 1H, CH Arom), 7.87 (dd, J=8.3, 1.9Hz, 1H, CH Arom), 8.13 (d, J=1.9Hz, 1H, CH Arom); 13C NMR (75MHz, CDCl3) delta=52.54, 128.63, 129.94, 130.52, 131.53, 132.92, 137.56, 165.21; MS (EI) (70eV), m/z (%): 208 (5) [M+4]+, 206 (31) [M+2]+, 204 (50) [M]+, 177 (10), 175 (62), 173 (100), 145 (30), 109 (20), 74 (18).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1805-32-9, its application will become more common.
Reference:
Article; Mirza-Aghayan, Maryam; Zonoubi, Somayeh; Molaee Tavana, Mahdieh; Boukherroub, Rabah; Ultrasonics Sonochemistry; vol. 22; (2015); p. 359 – 364;,
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