Related Products of 30379-58-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 30379-58-9, name is Benzyl 2-hydroxyacetate. A new synthetic method of this compound is introduced below.
To a tetrahydrofuran (40.0 mL) solution of the compound (3.68 g, 10.0 mmol)obtained in above Process 1 and benzyl glycolate (4.99 g, 30.0 mmol), potassium tertbutoxide (2.24 g, 20.0 mmol) was added at OC and stirred at room temperature for 15 minutes. The reaction solution was charged with ethyl acetate and water at OC and extracted with ethyl acetate and chloroform. The obtained organic layer was dried over sodium sulfate and filtered. The solvent was removed under reduced pressure. The obtained residues were dissolved in dioxane (40.0 mL) and water (10.0 mL), charged with sodium hydrogen carbonate (1.01 g, 12.0 mmol) and 9-fluorenylmethyl chloroformate (2.59 g, 10.0 mmol), and stirred at room temperature for 2 hours. The reaction solution was charged with water and extracted with ethyl acetate. The obtained organic layer was dried over sodium sulfate and filtered. The solvent was removed under reduced pressure and the obtained residues were purified by silica gel column chromatography [hexane: ethyl acetate = 100 : 0 (v/v) – 0: 1001 to yield the titled compound in colorless oily substance (1.88 g, 40%).1HNMR (400 MHz, CDC13) delta: 3.84 (2H, d, J = 5.5 Hz), 4.24 (3H, t, J = 6.5 Hz),4.49 (2H, d, J = 6.7 Hz), 4.88 (2H, d, J = 6.7 Hz), 5.15-5.27 (1H, m), 5.19 (2H, s), 6.74(1H, brs), 7.3 1-7.39 (7H, m), 7.43 (2H, t, J = 7.4 Hz), 7.61 (2H, d, J = 7.4 Hz), 7.79(2H, d, J = 7.4 Hz).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,30379-58-9, its application will become more common.
Reference:
Patent; DAIICHI SANKYO COMPANY, LIMITED; HETTMANN, Thore; ABRAHAM, Reimar; BLUM, Sabine; UENO, Suguru; WO2015/155998; (2015); A1;,
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