Reference of 27129-87-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 27129-87-9 as follows.
1-(chloromethyl)-3,5-dimethylbenzene was prepared from (3,5-dimethylphenyl)methanol and thionyl chloride: thionyl chloride (300 muL, 4.13 mmol, 11.8 M) and (3,5-dimethylphenyl)methanol (50 muL, 0.39 mmol, 1.1 M) were added to a NMR tube, capped. Teflon wrapping around the cap of nmr tube was used to prevent reaction mixture from leaking out. The NMR tube was heated at reflux under air (100 C) for 10 min. After cooling to 23 C, the nmr cap was replaced by a septum and volatiles were removed under vacuum via a needle through the septum. A solution (300 muL) of (1,4-bis(trifluoromethyl)benzene in C6D6 was added to the product mixture for 1H{13C} NMR analysis. All (3,5-dimethylphenyl)methanol was converted at the end of reaction. 1H{13C} NMR chemical shifts of 1-(chloromethyl)-3,5-dimethylbenzene: 6.75 ppm (2H, arene CH, s), 6.68 ppm (1H, arene CH, s), 4.15 ppm (2H, CH2Cl, s), 2.04 ppm (6H, benzylic CH3, s). 13C{1H} NMR chemical shifts of 1-(chloromethyl)-3,5-dimethylbenzene: 138.3 (s), 138.8 ppm (s),130.7 ppm (s), 127.4 ppm (s), 46.97 ppm, 21.65 ppm (s).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,27129-87-9, its application will become more common.
Reference:
Article; Zhou, Meng; Goldman, Alan S.; Molecules; vol. 20; 6; (2015); p. 10122 – 10130;,
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