Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 23783-42-8, name is 2,5,8,11-Tetraoxatridecan-13-ol. A new synthetic method of this compound is introduced below., Safety of 2,5,8,11-Tetraoxatridecan-13-ol
Example 3. Allyl 2,2-bis(2,5,8,11,14-pentaoxadodecyl)-4,7,10,13,16-pentaoxatetradecyl ether (compound 5 of Scheme 1 wherein n=4) Tetraethyleneglycol monomethyl ether (1.91 ml, 9 mmol) dissolved in dry and degassed DMF (3.5 ml) was carefully added to sodium hydride (365 mg, 9 mmol) in dry and degassed DMF (15 ml) under nitrogen at 0 C using a syringe. The temperature was then raised to room temperature and the reaction mixture was stirred for another 30 min. Tribromide 4 (730 mg, 2.0 mmol, example 1) was then added and the temperature was raised to 100 C, After 14 h the reaction was completed and the temperature was decreased to room temperature whereupon the reaction mixture was slowly added to H2O (150 ml). The H2O-phase was washed with diethyl ether (2 x 50 ml). Sodium chloride was then added to the H2O-phase until saturation. The H2O-phase was extracted with EtOAc (4 x 50 ml) and the combined organic phases were washed with brine (2 x 30 ml). Sodium sulfate and charcoal was added to the organic phase. The clear organic phase was filtered and the volatile material was removed at reduced pressure. Column chromatography (EtOAc:MeOH 9:1) gave 1.05 g of the product. 1H-NMR (CDCl3); 5.90 (m, 1H), 5.20 (m, 2H), 3.94 (dt, 2H), 3.70-3.55 (m, 48H), 3.45 (s, 6H), 3.43 (s, 2H), 3.40 (s, 9H).
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Reference:
Patent; Spago Imaging AB; Axelsson, Oskar; Ek, Fredrik; EP2573089; (2013); A1;,
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