Synthetic Route of 927-74-2, Adding some certain compound to certain chemical reactions, such as: 927-74-2, name is 3-Butyn-1-ol,molecular formula is C4H6O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 927-74-2.
A mixture of but-3-yn-1-ol (2.0 g, 28.6 mmol), imidazole (2.9 g, 42.9mmol), and DMAP (catalytic amount) was dissolved in anhydrousTHF (8 mL) under N2. A solution of tert-butyldimethylsilyl chloride (5.17 g, 34.3 mmol) in anhydrous THF (2 mL) was added dropwise and the mixture was stirred at r.t. for 2 h under N2. The mixture was quenched with sat. aq NH4Cl (20 mL) and extracted with hexane (3 ×20 mL). The combined organic layers were washed with brine (25mL), dried (Na2SO4), and concentrated under reduced pressure. Theresidue was purified by flash chromatography on silica gel (hexane) to afford compound 16 as a colorless oil; yield: 4.46 g (85%); Rf = 0.23 (hexane).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 927-74-2, 3-Butyn-1-ol, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Puigmarti, Marc; Bosch, Ma Pilar; Guerrero, Angel; Synthesis; vol. 47; 7; (2015); p. 961 – 968;,
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