Adding a certain compound to certain chemical reactions, such as: 558-42-9, 1-Chloro-2-methyl-2-propanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C4H9ClO, blongs to alcohols-buliding-blocks compound. Formula: C4H9ClO
To a solution of 1 -methyl-6-(6-(2-(piperidin-4-yl)ethoxy)-5-(trifluoromethyl)- pyridin-3-yl)-1 H-[1 ,2,3]triazolo[4,5-c]pyridine-4-carbonitrile trifluoroacetate (70 mg) and Lambda/,/V-diisopropylethylamine (85 mg) in acetonitrile (2 ml), 1 -chloro-2-methyl- propan-2-ol (48 mg) and sodium iodide (19 mg) were added and heated in microwave at 160 °C for 0.5h. The reaction mixture was concentrated then diluted with dichloromethane and water, extracted with dichloromethane and separated by hydrophobic frits, concentrated. Purified by Strata Si column (5g,dichloromethane:methanol=1 :0, 25:1 , 15:1 , 12.5:1 to 10:1 ) then passed through Strata SCX column (1 g) to give 20.0mg yellow amorphous as 6-(6-(2-(1 -(2-hydroxy- 2-methylpropyl)piperidin-4-yl)ethoxy)-5-(trifluoromethyl)pyridin-3-yl)-1 -methyl-1 H- [1 ,2,3]triazolo[4,5-c]pyridine-4-carbonitrile (31 percent).1H NMR (CD3OD-d4)5: 9.16 (s, 1 H), 8.75 (s, 1 H), 8.66 (s, 1 H), 4.59 (t, 2H, J=6.4Hz), 4.46 (s, 3H), 2.98 (t, 2H, J=1 1 .6Hz), 2.30 (s, 2H), 2.23 (d, 2H, J=1 1 .6Hz), 1 .70-1.85 (q+d, 4H), 1 .45-1 .60 (br, 1 H), 1 .38 (dq, 2H, J=12.0Hz, 3.30Hz), 1 .17 (s, 6H). MS m/z: 504 (M+H).
The synthetic route of 558-42-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; N.V. ORGANON; CAI, Jiaqiang; BENNETT, David, Jonathan; JONES, Philip, Stephen; WO2011/86125; (2011); A1;,
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