Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 5333-42-6, name is 2-octyldodecan-1-ol. A new synthetic method of this compound is introduced below., category: alcohols-buliding-blocks
2-octyldecanol (2-Octyldecanol) (4.3 g, 14.5 mmol)Anhydrous DMFIt was dissolved in0 In NaH (60% dispersion inparaffin) (0.58 g, 14.5 mmol) to It was added. After stirring 1 hour the reaction solution at 0 With 5,6-difluoro-benzo [c] [1,2,5] – thiadiazole was added (1 g, 5.8 mmol). Then, and after stirring at room temperature for 12 hours to terminate the reaction was added to a saturated NH4Cl solution and extracted with 100 mL of diethyl ether.The extract solution after silica gel column chromatography was concentrated by vacuum distillation (DCM: Hexanes (1: 3)) to give the compound through a 1 (4.0 g, 95% yield).
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Reference:
Patent; Korea Research Institute of Chemical Technology; Lee, Jong Chul; Mun, Sang Jin; Sin, Won Suk; Lee, Sang Gyu; Song, Chang Uhn; Soh, Won Wook; Woo, Han Young; (18 pag.)KR2016/31958; (2016); A;,
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