Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 100-86-7, name is 2-Methyl-1-phenyl-2-propanol. A new synthetic method of this compound is introduced below., COA of Formula: C10H14O
5,49 g of trifluoromethane sulfonic acid was added dropwise to a mixture of 1,2 g (7,3 mmol) 5,6-dimethoxy-pyridine-3-carbonitrile an6 1,1 g (7,3 mmol) ) 2-methyl-1-phenyl-propan-2-ol in 50 ml dichloromethane at -5C. After 30 minutes the reaction mixture was poured onto sodium hydrogencarbonate solution, the organic layer was separated and the aqueous layer was extracted twice with dichloromethane. The combined organic extracts were evaporated and the residue was purified via silica gel chromatography with heptane/ethyl acetate mixtures to yield 1.8 g (83 %) of the title compound as a yellow oil. 1H-NMR(CDCI3, delta in ppm): 7.9 (d, 1 H); 7,4 (m, 1 H); 7,35 (d, 1 H); 7,25 (m, 3H); 4,1 (s, 3H); 3,95 (s, 3H); 2,8 (s, 2H); 1,3 (s, 6H).
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Reference:
Patent; BASF SE; GRAMMENOS, Wassilios; WINTER, Christian; MUELLER, Bernd; WOLF, Antje; ESCRIBANO CUESTA, Ana; CAMBEIS, Erica; LOHMANN, Jan Klaas; GROTE, Thomas; KRETSCHMER, Manuel; RIEDIGER, Nadine; CRAIG, Ian Robert; WIEBE, Christine; TERTERYAN-SEISER, Violeta; KOCH, Andreas; FEHR, Marcus; (298 pag.)WO2017/16915; (2017); A1;,
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