Related Products of 111-46-6 ,Some common heterocyclic compound, 111-46-6, molecular formula is C4H10O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Protocole 2 To a solution of diethylene glycol (31.83 g ; 300.0 mmol ; 7.0 eq) in CH2Cl2 (90 mL) was added Et3N (4.77 g ; 47.1 mmol ; 1.1 eq). The mixture was stirred vigorously. A solution of p-toluenesulfonyl chloride (8.17 g ; 42.8 mmol ; 1.0 eq) in CH2Cl2 (108 mL) was added dropwise. Following the addition, the reaction mixture was stirred for 24 h at room temperature. Then a 1.0 M solution of HCl (50 mL), water (50 mL) and saturated solution of brine (60 mL) were added. The resultant aqueous layers were further extracted with CH2Cl2. The combined organic layers were dried over MgSO4, filtered and concentrated under reduced pressure. The product was purified by flash column chromatography on silica gel (99% CH2Cl2/MeOH) to give the desired compound 3b as a colorless oil in 67% yield (7.48 g).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 111-46-6, 2,2′-Oxybis(ethan-1-ol), other downstream synthetic routes, hurry up and to see.
Reference:
Article; Ricco, Christophe; Abdmouleh, Fatma; Riccobono, Charlotte; Guenineche, Lena; Martin, Frederique; Goya-Jorge, Elizabeth; Lagarde, Nathalie; Liagre, Bertrand; Ali, Mamdouh Ben; Ferroud, Clotilde; Arbi, Mehdi El; Veitia, Maite Sylla-Iyarreta; Bioorganic Chemistry; vol. 96; (2020);,
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