Reference of 7218-43-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 7218-43-1, name is 2-[2-(2-Propynyloxy)ethoxy]ethanol. A new synthetic method of this compound is introduced below.
A suspension of Intermediate B (190 mg, 0.297 mmol), 2-(2-(prop-2-yn-1-yloxy)ethoxy) ethanol [King-Underwood et al., WO2011/048111] (257 mg, 0.890 mmol), PdCI2(PPh3)2 (208 mg, 0.297 mmol) and copper(l) iodide (57 mg, 0.30 mmol) in a mixture of Et2NH and DMF (4: 1 v/v, 7.5 ml_) was degassed with N2 and was then heated to 60C for 16 hr. The reaction mixture was cooled to RT and was evaporated in vacuo onto silica gel and purified by flash column chromatography (Si02, 12 g, MeOH in DCM, 0-5%, gradient elution) to afford the title compound, Compound (la), as a pale tan solid (30 mg, 14%); Rt 1.88 min, m/z 704 (M+H)+ (ES+); 1 H NMR delta: 3.36-3.50 (6H, overlapping m), 3.61-3.63 (2H, overlapping m), 4.37 (2H, s), 4.58 (1 H, m), 5.48 (2H, s), 5.76 (2H, s), 6.41 (1 H, d), 6.64 (1 H, m), 6.72 (1 H, d), 6.78 (1 H, s), 7.14 (1 H, t), 7.27 (1 H, t), 7.52 (1 H, d), 7.65-7.71 (2H, overlapping m), 7.82 (1 H, t), 8.13 (1 H, s), 10.19 (1 H, br s).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,7218-43-1, its application will become more common.
Reference:
Patent; RESPIVERT LIMITED; ONIONS, Stuart Thomas; COPMANS, Alex Herman; BROECKX, Rudy Laurent Maria; SMITH, Alun John; TADDEI, David Michel Adrien; WO2014/140597; (2014); A1;,
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