Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 16545-68-9, name is Cyclopropanol. A new synthetic method of this compound is introduced below., name: Cyclopropanol
To a solution of 4-bromo-2-fluoropyridine (3000 mg, 17.05 mmol) and cyclopropanol (1287 mg, 22.16 mmol) in NMP (22.6 mL) was added sodium tert-butoxide (22.7 mL, 22.67 mmol) . After 50 min, the reaction mixture was partitioned between ethyl acetate and water (100 mL) . The organic layer was separated, washed with water, brine, dried over Na2SO4,filtered and concentrated. The resulting residue was purified by a flash column chromatography on silica gel (ISCO 40g SiO2column, eluting with 0-25% EtOAc/hexanes) to afford the title compound.
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 16545-68-9, Cyclopropanol.
Reference:
Patent; MERCK SHARP & DOHME CORP.; DEBENHAM, John S.; COX, Jason M.; LAN, Ping; SUN, Zhongxiang; FENG, Zhe; SUN, Chunrui; SEGANISH, W. Michael; LAI, Zhong; ZHU, Chen; BARA, Thomas; RAJAGOPANALAN, Murali; DANG, Qun; KIM, Hyunjin M.; HU, Bin; HAO, Jinglai; (112 pag.)WO2018/107415; (2018); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts