Synthetic Route of 7314-44-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 7314-44-5, name is (2,4-Dimethoxyphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.
TMS protected treprostinil was dissolved in DCM (2.5 mE) and H20 (60 pL). DMAP (76 mg, 0.624 mmol),EDC.HC1 (119 mg, 0.624 mmol) and Dmob-alcohol (105 mg, 0.624 mmol) dissolved in DCM (1 ml) were added. Thereaction mixture was stirred at RT until reaction was com25 plete (EC/MS). The solution was diluted with DCM andquenched by addition of 0.1 N HC1 solution saturated withNaC1. The aqueous phase was extracted several times withDCM. Combined organic layers were dried with Mg504 andthe solvent was removed in vacuo obtaining crude product8. Crude product was purified using RP-HPEC (solvent A:H20 with 0.05% TFA, solvent B: MeCN with 0.05% TFA, gradient: 35-85% B over 16 mm, flow: 40 ml/min). Combined HPEC fractions were adjusted to a pH of approx. 7 by adding sat. NaHCO3 soln. MeCN was removed in vacuo. The remaining H20 layer was extracted several times with DCM and the combined organic phases were dried with Mg504, filtered and the solvent was removed in vacuo obtaining product 8 as colorless solid.Yield: 69 mg (82%).MS: mlz 563.20 g/mol=[M+Na] (MW+Na calculated=563.67 g/mol).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 7314-44-5, (2,4-Dimethoxyphenyl)methanol.
Reference:
Patent; Ascendis Pharma A/S; Hersel, Ulrich; Rau, Harald; Lessmann, Torben; Bisek, Nicola; Maitro, Guillaume; Sprog°e, Kennett; Wegge, Thomas; Keil, Oliver; Zettler, Joachim; (89 pag.)US9561287; (2017); B2;,
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