Adding a certain compound to certain chemical reactions, such as: 16369-21-4, 2-(Propylamino)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 16369-21-4, blongs to alcohols-buliding-blocks compound. Formula: C5H13NO
A mixture of 2-(propylamino)ethanol (41 mg, 0.397 mmol) and (R)-1-(3-((3′-(3- bromopropoxy)-2,2′-dimethyl-[1,1′-biphenyl]-3-yl)oxy)propyl)pyrrolidin-3-ol (20 mg, 0.043 mmol) in methanol (1.0 mL) and N,N-diisopropylethylamine (40 muL, 0.229 mmol) was heated at 65-70 C for 72 h. The crude material was purified via preparative LC/MS with the following conditions: Column: XBridge C18, 19 x 200 mm, 5-mum (0379) particles;Mobile Phase A: 5:95 acetonitrile: water with 10-mM ammonium acetate; Mobile Phase B: 95:5 acetonitrile: water with 10-mM ammonium acetate; Gradient: 20- 60% B over 15 minutes, then a 5-minute hold at 100% B; Flow: 20 mL/min to give the pure title compound: (12.5 mg, 59%). LC/MS Condition E: ret time 1.27 min; m/e = 485 (M+H)+; LC/MS Condition F: ret time 1.22 min; m/e = 485 (M+H)+.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,16369-21-4, its application will become more common.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; YEUNG, Kap-Sun; GRANT-YOUNG, Katharine A.; ZHU, Juliang; SAULNIER, Mark G.; FRENNESSON, David B.; LANGLEY, David R.; HEWAWASAM, Piyasena; WANG, Tao; ZHANG, Zhongxing; MENG, Zhaoxing; SUN, Li-Qiang; MULL, Eric; SCOLA, Paul Michael; (370 pag.)WO2018/44963; (2018); A1;,
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