Reference of 53463-68-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 53463-68-6, name is 10-Bromodecanol, molecular formula is C10H21BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
10-Bromodecan-1-ol (0.24 g, 1.0 mmol) in dry THF (1mL) was mixed with 3,4-dihydro-2H-pyran (0.11 g, 1.25 mmol) and iodine (0,05 g, 0.2 mmol). The mixture was added to a 50 mL conical flask, and a small funnel was placed over it to reduce possible evaporation of solvent. The flask was irradiated in microwave oven at 600 MW power for 3min. On cooling, the reaction mixture was diluted with chloroform (30 mL) and washed with 10percent aq. sodium thiosulphate solution (2 x 5 mL), water (2 x 5 mL), brine and dried. Evaporation of the solvent under reduced pressure and purification by silica gel column chromatography (1:9 ethyl acetate: n-hexane) furnished 10-bromo-1-tetrahydropyranyloxydecane (0.30 g, 94percent) as a colourless oil.
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Reference:
Article; Kaur, Jasamrit; Kaur, Irvinder; Jindal, Gitanjali; Manhas, Priya; Gupta, Neeru; Singh, Jasvinder; Journal of Chemical Research; vol. 39; 4; (2015); p. 230 – 232;,
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