Adding a certain compound to certain chemical reactions, such as: 504-63-2, 1,3-Propanediol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 504-63-2, blongs to alcohols-buliding-blocks compound. Recommanded Product: 504-63-2
Propane-1,3-diol (5.0 g, 65.78 mmol) was taken in 50 mL of dry THF. Next, NaH (60% dispersion in mineral oil, 2.49 g, 65.78 mmol) was added in portions at 0 C. The reaction mixture was stirred at 0 C for 30 min. Tetrabutylammonium iodide (TBAI) (1.6 g, 0.66 mmol) was added to it followed by the addition of 4-methoxybenzylbromide (13.2 g, 65.78 mmol) in THF (50 mL). The reaction mixture was stirred for a further 2 h at room temperature. Ice water (15 mL) was added carefully to the reaction mixture to quench any excess of NaH. The reaction mixture was extracted with EtOAc (50 mL). The organic layer was washed with water (15 mL) and brine (20 mL). Evaporation and purification by means of silica gel chromatography (EtOAc/hexane = 20:80) afforded compound 8 (11.6 g, 90%) as a colorless liquid. IR: nu 3393, 1613, 1513, 1462, 1248 cm-1; 1H NMR (200 MHz, CDCl3): 7.22 (2H, d, J = 8.0 Hz), 6.83 (2H, d, J = 8.0 Hz), 4.41 (2H, s), 3.79 (3H, s), 3.70 (2H, d, J = 7.0 Hz), 3.56 (2H, d, J = 7.0 Hz), 2.52 (1H, br s), 1.86-1.74 (2H, m); 13C NMR (50 MHz): delta; ESIMS: m/z 197 [M+H]+, Anal. Calcd for C11H16O3: C, 67.35; H, 8.16. Found: C, 67.46; H, 8.11.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,504-63-2, its application will become more common.
Reference:
Article; Das, Biswanath; Nagendra, Siddavatam; Reddy, Cheruku Ravindra; Tetrahedron Asymmetry; vol. 22; 11; (2011); p. 1249 – 1254;,
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