Reference of 395-23-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.395-23-3, name is Phenyl(4-(trifluoromethyl)phenyl)methanol, molecular formula is C14H11F3O, molecular weight is 252.2318, as common compound, the synthetic route is as follows.
General procedure: A solution of diphenylmethanol (1 mmol), NBS (1.3equiv.), KOAc (1.5 equiv.) H2O (1.5 mL), and CH2Cl2 (0.5mL) was magnetically stirred in 25 mL flask at room temperaturefor 10 h. The reaction mixture was added into water(10 mL), and extracted with EtOAc (3 × 10 mL). The combinedEtOAc extracts were dried over anhydrous MgSO4,filtrated, and then the solvent was removed under reducedpressure. The residue was purified by the flash columnchromatography on silica gel with PE or PE/EtOAc as theeluent to obtain the desired products. The oxidation productswere identified by GC-MS and 1H NMR.
Statistics shows that 395-23-3 is playing an increasingly important role. we look forward to future research findings about Phenyl(4-(trifluoromethyl)phenyl)methanol.
Reference:
Article; Wu, Jianglong; Liu, Yan; Liu, Ping; Gu, Chengzhi; Letters in Organic Chemistry; vol. 14; 4; (2017); p. 254 – 260;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts