Related Products of 34231-22-6 ,Some common heterocyclic compound, 34231-22-6, molecular formula is C8H11NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To 3-(difluoromethyl)-i -methyl- 1H-pyrazole-4- carboxylic acid (1.5 g, 8.52 mmol) was added dropwise 20 mE sulthryl dichloride, and then heated to reflux for 3 h, the excessive sulfuryl dichloride was evaporated under reduced pressure to get 3-(difluoromethyl)-i -methyl- 1H-pyrazole-4- carbonyl chloride, and then the carbonyl chloride was dissolved in 30 mE dichloromethane for the following reaction. To a cooled solution of (3-(aminomethyl)phenyl)methanol (1.17 g, 8.52 mmol) dissolved in 20 mE dichloromethane and 5 mE triethylamine was added dropwise the solution of the carbonyl chloride at 0-5 C. After the reaction was stirred for 6 h at room temperature, analysis by Thin-Layer Chromatography showed complete conversion to product, the excessive solvent was evaporated under reduced pressure. the residual was purified by column chromatography on silica gel (eluent: ethyl acetate:petroleum ether=i :3; silica gel: 100-140 mesh, Qingdao Marine Chemical Co., Ltd.) to obtain 3-(difluoromethyl)-N-(3-(hydroxymethyl)benzyl)-i – methyl-1H-pyrazole-4-carboxamide (1.8 g) as white solid with yield of 72%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 34231-22-6, 3-(Aminomethyl)benzyl Alcohol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Shenyang Sinochem Agrochemicals R&D Co., Ltd.; CHENG, Xueming; ZHANG, Lixin; CHEN, Liang; SUN, Qin; LIU, Junli; LI, Zhinian; ZHAO, Jie; XU, Jingbo; WU, Hongfei; (60 pag.)US2018/362450; (2018); A1;,
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