Reference of 626-18-6 ,Some common heterocyclic compound, 626-18-6, molecular formula is C8H10O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a solution of 1,3-benzenedimethanol (1 g) in tetrahydrofuran (10 mL) was added sodium hydride (60%, 318 mg) under ice-cooling, and the mixture was stirred for 30 minutes. To the reaction mixture was added tert-butyldimethylsilyl chloride (1.09 g), and the mixture was stirred at room temperature for 4 days. Ice water was added to the reaction mixture, and the resulting mixture was extracted with diethyl ether. The extract was washed with water and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure, and the residue was purified by column chromatography on silica gel (eluent: hexane/ethyl acetate = 5/1) to give the title compound (528 mg).1H-NMR (CDCl3) delta ppm: 0.10 (6H, s), 0.95 (9H, s), 1.59 (1H, t, J=5.9Hz), 4.70 (2H, d, J=5.9Hz), 4.75 (2H, s), 7.20-7.40 (4H, m)
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 626-18-6, 1,3-Benzenedimethanol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Kissei Pharmaceutical Co., Ltd.; EP1400529; (2004); A1;,
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