As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4541-15-5, name is 5-(Benzyloxy)pentan-1-ol, molecular formula is C12H18O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 5-(Benzyloxy)pentan-1-ol
Et3N (10.79 mL, 78 mmol) was added in one portion via syringe to a solution of 5-Benzyloxy-1- pentanol (10.08 g, 51.9 mmol) in DCM (75 mL) in a round bottom flask charged with a magnetic stir bar at 0 C under N2. Next, MsCI (4.85 ml_, 62.3 mmol) was added dropwise via syringe in 4 separate portions at a rate such that the internal temperature did not exceed 15 C. The reaction was allowed to continue to stir for 1 hour, after which it was diluted with H20 (200 ml_) and DCM (150 ml_). The organic layer was separated, and the aqueous layer was washed with DCM (225 ml_). The combined organic layers were washed with brine (200 ml_), dried with Na2S04, filtered, and concentrated under reduced pressure to provide the title compound as a crude orange oil (14.46 g). MS (M + 1 ) = 272.9, Rt = 1.33 min (LC method 13).
With the rapid development of chemical substances, we look forward to future research findings about 4541-15-5.
Reference:
Patent; NOVARTIS AG; BRITO, Luis; CHEN, Delai; GAMBER, Gabriel Grant; GEALL, Andrew; LOVE, Kevin; ZABAWA, Thomas; ZECRI, Frederic; WO2015/95340; (2015); A1;,
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