Adding a certain compound to certain chemical reactions, such as: 623-72-3, Ethyl 3-Hydroxypropanoate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 623-72-3, blongs to alcohols-buliding-blocks compound. SDS of cas: 623-72-3
EXAMPLE 42 In 5 ml of tetrahydrofuran was dissolved 1.12 g of diethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine- 3,5-dicarboxylate and after adding to the solution 0.17 g of 50% oil dispersion of sodium hydride at room temperature, the resultant mixture was stirred for 30 minutes at room temperature. Then, the mixture was cooled to -30 C., and after adding dropwise thereto 0.74 g of 1,3-propansultone, the temperature of the system was raised till room temperature and the reaction mixture was stirred for 3 days at room temperature. The reaction solution was concentrated and the precipitate formed was washed with 30 ml of ether. This precipitate was dissolved in 2 ml of water and the solution obtained was subjected to a silica gel (30 g) column chromatography. After eluding the small amount of raw material using ethyl acetate as an elute, the product was then developed by using 1:1 ethyl acetatemethanol mixed solvent as an elute and the solvent of the effluent was distilled away under reduced pressure. To the residue obtained was added 2 ml of water and after cooling, the crystal formed was filtered to provide 0.35 g of sodium alpha-[2,6-dimethyl-3,5-bis(ethoxycarbonyl)-4-(3-nitrophenyl)-1,4-dihydropyridin-1-yl] propylsulfonate. Nuclear magnetic resonance (CDCl3): signal of 6.0 PPM of raw material (1H, S, proton at 1-position) vanished.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,623-72-3, Ethyl 3-Hydroxypropanoate, and friends who are interested can also refer to it.
Reference:
Patent; Yamanouchi Pharmaceutical Co., Ltd.; US4021434; (1977); A;,
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