Reference of 100-86-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 100-86-7, name is 2-Methyl-1-phenyl-2-propanol, molecular formula is C10H14O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: To a solution of the corresponding alcohol (1.0 mmol) in CH2Cl2 (3 mL) were added N-methylmorpholine (101 mg, 1.0 mmol) and ethyl propiolate (108 mg, 1.1 mmol). The reaction mixture was stirred at r.t., and the progress of the reaction was monitored by TLC. After completion of the reaction, the solvent was removed on a rotary evaporator and the residue was extracted with EtOAc (3 × 10 mL). The combined organic extracts were washed with brine (30 mL), and dried over anhyd Na2SO4. The solvent was removed on a rotary evaporator, and the crude product was purified by silica gel column chromatography using EtOAc and hexane as eluents.
According to the analysis of related databases, 100-86-7, the application of this compound in the production field has become more and more popular.
Reference:
Article; Sarkar, Sujit; Sultana, Sabera; Indukuri, Kiran; Unnava, Ramanjaneyulu; Saikia, Anil K.; Synthesis; vol. 48; 11; (2016); p. 1727 – 1733;,
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