Synthetic Route of 124937-73-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 124937-73-1, name is 3-(2-Methoxy-5-methylphenyl)-3-phenylpropan-1-ol. A new synthetic method of this compound is introduced below.
Dimethylsulfoxide (DMSO) (6.72 ml, 94.6 mmol) in 20 ml of Cl2CH2 was added to a mixture of oxalyl chloride (4.06 ml, 47.3 mmol) in 100 ml of Cl2CH2 and cooled at -78C, always maintaining the reaction temperature under -60C. It was allowed to take place at said temperature for 15 minutes and then a mixture of 3-(2-methoxy-5-methylphenyl)-3-phenylpropanol (9.33g, 36.4 mmol) in 40ml of Cl2CH2 was added. The reaction mixture was maintained for about 45 minutes and triethylamine (25.72 ml, 0.18 mol) was added. The crude reaction product was maintained reacting for about 1 hour and hydrolyzed with 100 ml of NaHCO3 (7%). The extraction was carried out with 100 ml of ethyl acetate. The organic phase was washed with 2x25ml of HCl (5%), dried and evaporated, giving 8.67g (94%) of a viscous orangish liquid containing the title compound.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,124937-73-1, 3-(2-Methoxy-5-methylphenyl)-3-phenylpropan-1-ol, and friends who are interested can also refer to it.
Reference:
Patent; Ragactives, S.L.; EP1698615; (2006); A1;,
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