Electric Literature of 1562-00-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1562-00-1, name is Sodium isethionate, molecular formula is C2H5NaO4S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Preparation of Dowex 1×8 HES. Dowex 1×8 Cl (5 g) was suspended in a minimum amount of water (10 mL), stirred for 10 min and filtered. The residue was suspended in a freshly prepared sodium isethionate (3.7 g, 25 mmol) solution in water (10 mL). The mixture was stirred for 10 min, filtered and the residue was washed with water (50 mL x 3) and methanol (50 mL x 3) successively. The resin was dried by vacuum suction for 15 min to give Dowex 1×8 isethionate (4.0 g, 0.96 milliequivalent/g).Synthesis of COHPyrv-24-HES. To a solution of CoHPyrv-24 (30 mg, 0.04 mmol) in 50:50, MeOH: H20 (1 .5 ml.) was added Dowex 1×8 isoethionate (0.21 g, 0.2 meq) and the mixture was stirred at room temperature for 30 min. The resulting mixture was then filtered and washed with water, 50:50 Me()H 20 and MeOH successively (50 mL total vol .) until the resin turned colorless. The filtrate was concentrated and dried under high vacuum to give 29 mg of the title compound.
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Reference:
Patent; CITY OF HOPE; JONES, Jeremy; PAL, Sumanta, Kumar; (187 pag.)WO2017/41040; (2017); A1;,
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