Related Products of 14320-38-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 14320-38-8, name is Cyclopent-3-enol. This compound has unique chemical properties. The synthetic route is as follows.
Cyclopent-3-en-1-yl 4-methylbenzenesulfonate To a solution of cyclopent-3-ene-1-ol (70.2 g, 835 mmol) in pyridine (150 mL) and DCM (300 ml) cooled at 4 C. under N2 atm was added slowly with stirring 4-toluene-sulfonyl chloride (175 g, 918 mmol). The mixture was then stirred under N2 atm at this temperature for 1 h, then stood in cold room at 4 C. for 48 h. Most of the dichloromethane was evaporated at reduced pressure. The mixture was diluted with EtOAc/Hexane (20%, 600 ml) and washed with water (5*) and brine. The aqueous phases were back extracted with EtOAc/hexanes (20%, 1*400 ml), the organic layers combined, dried over MgSO4, and then filtered through a short plug (3 cm*11 cm) of silica (washed with a further 1000 ml 20% EtOAc/Hexane). The solvent was evaporated at reduced pressure to give a colorless oil. The residual solvent in the crude product was azeotroped with hexanes then twice with toluene. The resulting colorless oil was further dried by azeotroping once with hexanes and then crystallizing by diluting with an equal volume of hexane and heating at 50 C. The resulting biphasic mixture of colorless oil and solids in hexanes was allowed to age at RT overnight. The solid was removed by filtration and washed with cold hexanes and then dried in-vacuum to give the title compound (173 g, 727 mmol, 87%). 1H NMR (CHLOROFORM-d) delta: 7.79 (d, J=7.9 Hz, 2H), 7.34 (d, J=7.9 Hz, 2H), 5.65 (s, 2H), 5.11-5.24 (m, 1H), 2.59-2.67 (m, 2H), 2.48-2.55 (m, 2H), 2.45 (s, 3H).
According to the analysis of related databases, 14320-38-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Board of Regents, The University of Texas System; LEWIS, Richard T.; HAMILTON, Matthew; JONES, Philip; PETROCCHI, Alessia; REYNA, Naphtali; MCAFOOS, Timothy; CROSS, Jason Bryant; SOTH, Michael J.; US2020/24236; (2020); A1;,
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