Related Products of 148043-73-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 148043-73-6, name is 4,4,5,5,5-Pentafluoropentan-1-ol. A new synthetic method of this compound is introduced below.
Synthesis of compound 17 A 250 ml flask containing a solution of compound 18 (20 g, 1 12.3 mmol) in 50 ml of dry acetonitrile under inert nitrogen atmosphere. Triethylamine (19.9 ml, 142.6 mmol) and a solution of Methanesulfonyl chloride (9.9 ml, 128 mmol) in 35 ml ACN were slowly added at a temperature below 20 C. The mixture was stirred at room temperature 4 h. The mixture was concentrated by evaporating most of the ACN and extracted with CH2CI2. The organic phase was washed with saturated NaCI solution, dried over anhydrous MgS04, filtered and evaporated to dryness. 24.45 g of a yellow liquid was obtained (122% by mass).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,148043-73-6, 4,4,5,5,5-Pentafluoropentan-1-ol, and friends who are interested can also refer to it.
Reference:
Patent; CRYSTAL PHARMA, S.A.U.; PEREZ ENCABO, Alfonso; TURIEL HERNANDEZ, Jose Angel; GALLO NIETO, Francisco Javier; LORENTE BONDE-LARSEN, Antonio; GARCIA ESCUDERO, Luis Angel; WO2015/181116; (2015); A1;,
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