Application of 5456-63-3, Adding some certain compound to certain chemical reactions, such as: 5456-63-3, name is trans-2-Aminocyclohexanol hydrochloride,molecular formula is C6H14ClNO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5456-63-3.
To a solution of 5,8-difluoro-1-[4-(1H-pyrazol-1-yl)benzyl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (100 mg) known from a document (Bioorganic and Medicinal Chemistry Letters, 2010, 20, 1334.) in DMF (4 mL) were added (1,2-trans)-2-hydroxycyclohexylamine hydrochloride (60 mg), N1-[(ethylimino)methylene]-N3,N3-dimethylpropane-1,3-diamine hydrochloride (75 mg), 1H-benzo[d][1,2,3]triazol-1-ol monohydrate (60 mg) and triethylamine (0.11 mL), and the mixture was stirred at room temperature for 15 hr. Water (10 mL) was added to the reaction solution, the mixture was stirred, and the precipitated solid was collected by filtration and dried to give the title compound (110 mg). MS (ESI+): [M+H]+ 479.3 1H NMR (400 MHz, DMSO-d6) delta 1.16-1.38 (4H, m), 1.54-1.70 (2H, m), 1.80-1.91 (1H, m), 1.97-2.07 (1H, m), 3.36-3.44 (1H, m), 3.61-3.71 (1H, m), 4.83 (1H, d, J = 4.9 Hz), 5.82 (2H, d, J = 2.4 Hz), 6.53 (1H, s), 7.20-7.33 (3H, m), 7.59-7.69 (1H, m), 7.72 (1H, s), 7.80 (2H, d, J = 8.3 Hz), 8.45 (1H, d, J = 2.4 Hz), 8.93 (1H, s), 9.81 (1H, d, J = 7.3 Hz).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 5456-63-3, trans-2-Aminocyclohexanol hydrochloride, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Takeda Pharmaceutical Company Limited; SAKAMOTO, Hiroki; SUGIMOTO, Takahiro; EP2821401; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts