Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 62285-58-9, name is (2,6-Dimethylphenyl)methanol. A new synthetic method of this compound is introduced below., Application In Synthesis of (2,6-Dimethylphenyl)methanol
Step C: Preparation of 3-(3-(2,6-dimethylbenzyloxy)phenyl)propanenitrile: A solution of 3-(3-hydroxyphenyl)propanenitrile (Step B, 1.25 g, 8.5 mmol) and diisopropyl azodicarboxylate (DIAD, 1.87 g, 9.26 mmol) in dry THF (10 ml) was added drop wise to a solution of 2.6-Dimethylbenzyl alcohol (1.27 g, 9.3 mmol) and triphenylphosphine (TPP. 2.43 g, 9.26 mmol) in dry THF (30 ml) at 0C under argon. The reaction mixture was warmed to room temperature for 4 hours or until all the starting material is consumed, diluted with ether and washed with water (2X). The organic layer was dried over Na3SO4. filtered, concentrated, and purified by flash chromatography on a silica gel column (hex: ethyl acetate 2:1) to give the title compound.
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 62285-58-9, (2,6-Dimethylphenyl)methanol.
Reference:
Patent; Wellstat Therapeutics Corporation; O’NEIL, James, Dennen; SHARMA, Shalini; ARUDCHANDRAN, Ramachandran; EP2282736; (2015); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts