Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1124-63-6, name is 3-Cyclohexylpropan-1-ol. A new synthetic method of this compound is introduced below., COA of Formula: C9H18O
General procedure: DMSO (14.0 mmol) was added dropwise to a stirred solution of oxalyl chloride (5.0 mmol) in DCM (20.0 mL) at -78 C and the resulting reaction mixture was stirred for 20 min at this temperature. Then 3-cyclohexyl-propanol or 3-pyridinepropanol (4.0 mmol) was added dropwise and stirred for 1 h followed by the addition of Et3N (1.0 mL). The reaction was gradually brought to room temperature and H2O was added. The separated DCM phase was washed with brine and purified by flash chromatography (Hexane/ethyl acetate (EtOAc) = 10/1) to give a colorless oil.
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Reference:
Article; Liu, Kai; Rao, Wei; Parikh, Hardik; Li, Qianbin; Guo, Tai L.; Grant, Steven; Kellogg, Glen E.; Zhang, Shijun; European Journal of Medicinal Chemistry; vol. 47; 1; (2012); p. 125 – 137;,
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