Related Products of 558-42-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 558-42-9, name is 1-Chloro-2-methyl-2-propanol, molecular formula is C4H9ClO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Compound 17 (214mg; 0.53mmol), 1 -chloro-2-methyl-2-propanol (0.13ml 1.28mmol), K2CO3 (147mg; 1.1 mmol) in DMF (9ml_) were heated to 120°C for 72 hours. The reaction mixture was cooled to room temperature, poured into H20/K2C03 and extracted with EtOAc. The organic layer was dried (MgS04), filtered and evaporated to dryness. The residue (277mg) was purified by chromatography over silica gel (Irregular SiOH, 15- 40mueta, 30g; mobile phase, gradient from 100percentDCM to 90percentDCM, 10percentMeOH,0.1 percentNH4OH) The pure fractions were collected and evaporated to dryness. The residue (226mg) was crystallized in diethyl ether, yielding 178mg (90percent) of compound 52.MP=159°C(DSC).
According to the analysis of related databases, 558-42-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ASTEX THERAPEUTICS LIMITED; SAXTY, Gordon; MURRAY, Christopher William; BERDINI, Valerio; BESONG, Gilbert Ebai; HAMLETT, Christopher Charles Frederick; JOHNSON, Christopher Norbert; WOODHEAD, Steven John; READER, Michael; REES, David Charles; MEVELLEC, Laurence Anne; ANGIBAUD, Patrick Rene; FREYNE, Eddy Jean Edgard; GOVAERTS, Tom Cornelis Hortense; WEERTS, Johan Erwin Edmond; PERERA, Timothy Pietro Suren; GILISSEN, Ronaldus Arnodus Hendrika Joseph; WROBLOWSKI, Berthold; LACRAMPE, Jean Fernand Armand; PAPANIKOS, Alexandra; QUEROLLE, Oliver Alexis Georges; PASQUIER, Elisabeth Therese Jeanne; PILATTE, Isabelle Noelle Constance; BONNET, Pascal Ghislain Andre; EMBRECHTS, Werner Constant Johan; AKKARI, Rhalid; MEERPOEL, Lieven; WO2011/135376; (2011); A1;,
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