As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 109-83-1, name is 2-(Methylamino)ethanol, molecular formula is C3H9NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. category: alcohols-buliding-blocks
4-Methoxy-2,6-dimethylbenzenesulfonyl chloride (12 g, 51 mmol) is added to a solution of 2- (methylamino)ethanol (4.6 mL, 61 mmoi), diisopropyl ethyl amine (22 mL, 130 mmol), and CH2Cl2 (130 mL) under N2. The reaction vessel is sealed and left to stir for 21 h. The solution is washed with 1 :1 sat. aq. NH4C.: H2O (2 X 200 mL) and brine (200 mL). The aqueous layers are extracted with CH2Cl2 (200 mL). The combined organic layers are dried over Na2SO4, filtered, and concentrated to afford the title compound as a pale yellow oil. LC-MS m/? (M + Na~): 296.06 (§).
With the rapid development of chemical substances, we look forward to future research findings about 109-83-1.
Reference:
Patent; NEUROGEN CORPORATION; WO2007/140383; (2007); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts