Application of 5456-63-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.5456-63-3, name is trans-2-Aminocyclohexanol hydrochloride, molecular formula is C6H14ClNO, molecular weight is 151.6345, as common compound, the synthetic route is as follows.
To a suspension of l-(2,4-dichlorophenyl)-4-hydroxymethyl-5-[4-(3,3,3-trifluoropropane- l-sulfonyloxy)phenyl]-lH-pyrazole-3-carboxylic acid (0.70 g, 1.30 mmol) in dichloromethane (90 ml) was added c-2-aminocyclohexanol hydrochloride (200 mg, 1.32 mmol) followed by triethylamine (0.37 ml, 2.63 mmol) and BOP (708 mg, 1.60 mmol). The reaction mixture was stirred at room temperature overnight, poured into ice- water and extracted with EtOAc (x3). The combined organic extracts were dried (Na2SO4), filtered and concentrated. Flash chromatography (heptane : EtOAc 50 : 50 – EtOAc) and CH2Cl2 : MeOH 99 : 1 – 95 : 5) afforded 200 mg (24%) of the title compound as a colorless solid. HPLC: 89%. MS: 658 (M+Na).
The chemical industry reduces the impact on the environment during synthesis 5456-63-3, I believe this compound will play a more active role in future production and life.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2007/148061; (2007); A1;; ; Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2007/148062; (2007); A1;,
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