Synthetic Route of 575-03-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 575-03-1, name is 7-Hydroxy-4-(trifluoromethyl)coumarin. This compound has unique chemical properties. The synthetic route is as follows.
To a 100 mL reaction flask was added 2.8 g (0.01 mol) of dihydroartemisinin and 1.01 g (0.01 mol) of triethylamine,30 mL of dry methylene chloride was added, stirred to dissolve, cooled to -5 ° C, and 1.4 mL (0.01 mol) of trifluoroacetic acid Anhydride, and the reaction was continued at 0 ° C for 8 hours to obtain 10-trifluoroacetoxy dihydroartemisinin in dichloromethane, without Need to be processed, directly for the next step reaction. To the solution prepared above, 2.3 g of 7-hydroxy-4-trifluoromethylcoumarin was added (0.01 mol), and the reaction was continued for 14 hours at room temperature (TLC monitoring reaction end point). To the reaction solution was further added 30 mLDichloromethane, the organic layer was separated and washed 5 times (5 x 20 mL) with saturated sodium bicarbonate solution, dried over anhydrous sodium sulfate Phase, the desiccant was filtered off and the dichloromethane was distilled off under reduced pressure to give the crude product which was purified by column chromatography (200-300 mesh silica gel, petroleum ether: acetic acid Ethyl ester = 8: 1) to give 2.53 g of a white solid in 51percent yield.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 575-03-1, 7-Hydroxy-4-(trifluoromethyl)coumarin.
Reference:
Patent; Shenyang Pharmaceutical University; Guo, Chun; Tian, Ye; Hou, Zhuang; Guo, Mengbi; Li, Jianteng; Mou, Yanhua; Xia, Mingyu; (25 pag.)CN106188088; (2016); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts