In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 30595-79-0, name is 2,6-Dichlorophenethyl alcohol, the common compound, a new synthetic route is introduced below. Safety of 2,6-Dichlorophenethyl alcohol
To a solution of 2-(2,6-dichlorophenyl)ethan- 1-ol (20 g, 104.68 mmol, 1.00 equiv) in pyridine (500 mL) was added sodium hydride (5.2 g,216.67 mmol, 1.25 equiv). The resulting solution was stirred at 0 C for 1 h. Then CuC1 (600 mg, 6.12 mmol, 0.05 equiv) was added. The resulting solution was stirred overnight at 115C. The resulting mixture was concentrated under vacuum. The reaction was then diluted with 500 mL of H20. The pH value of the solution was adjusted to 4 with HC1 (3 M). The solids were filtered out. The resulting solution was extracted with petroleum ether. And the organic layers were combined, dried over anhydrous sodium sulfate and concentrated under vacuum. The cmde product was purified by 5i02 chromatography, eluted with petroleum ether to afford 16 g (99%) of 4-chloro-2,3-dihydro-1-benzofuran as colorless oil.
The synthetic route of 30595-79-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; AUSPEX PHARMACEUTICALS, INC.; ZHANG, Chengzhi; CHAKMA, Justin; LAUFER, Ralph; (108 pag.)WO2016/109359; (2016); A1;,
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