With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.495-76-1, name is Benzo[d][1,3]dioxol-5-ylmethanol, molecular formula is C8H8O3, molecular weight is 152.1473, as common compound, the synthetic route is as follows.Computed Properties of C8H8O3
General procedure: In a typical reaction, the catalyst was weighed into a screw-capped glass pressure vessel containing a stir bar. The required amounts of alcohol (0.5 mmol) and amine (0.6 mmol), pre-dissolved in solvent (2 mL), were added and the vessel was filled with oxygen, sealed, and heated to the desired temperature in an oil bath with stirring. The products of the reaction were analyzed by gas chromatography (GC, Agilent 7890A) and GC-mass spectrometry (MS, Agilent 7890A/5975C).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,495-76-1, Benzo[d][1,3]dioxol-5-ylmethanol, and friends who are interested can also refer to it.
Reference:
Article; Zhang, Zhixin; Wang, Yehong; Wang, Min; Lue, Jianmin; Li, Lihua; Zhang, Zhe; Li, Mingrun; Jiang, Jingyang; Wang, Feng; Chinese Journal of Catalysis; vol. 36; 9; (2015); p. 1623 – 1630;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts