Related Products of 101597-25-5, Adding some certain compound to certain chemical reactions, such as: 101597-25-5, name is 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol,molecular formula is C17H16O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 101597-25-5.
Analogously to a literature procedure32 TMSCl (0.30mL, 2.4mmol) was added to a solution of alkyne 11g27 (0.46g, 1.7mmol), DMAP (11mg, 0.090mmol) and TEA (0.38mL, 2.7mmol) in THF (3mL) at 25C. After stirring for 4h at 25C the mixture was quenched with 85 H2O, extracted with Et2O, dried with Na2SO4 and evaporated to dryness. The crude product was purified by flash chromatography with PE/EtOAc (97:3). Colorless oil (510mg, 88%). IR (Film): =3283, 3000, 2956, 2903, 2836, 1607, 1585, 1507, 1464, 1441, 1415, 1303, 1249, 1195, 1172, 1119, 1079, 1035, 1024, 1006, 936, 916, 883, 842, 806, 782, 756, 636cm-1. 1H NMR (500MHz, CD2Cl2) delta 0.11 (s, 9H), 2.93 (s, 1H), 3.77 (s, 6H), 6.79-6.84 (m, 4H), 7.41-7.46 (m, 4H) ppm. 13C NMR (126MHz, CD2Cl2) delta 1.75, 55.77, 75.35, 76.94, 87.31, 113.71, 127.71, 139.29, 159.44ppm. HRMS (EI): [M]+ calcd. for C20H24O3Si, 340.1495; found 340.1486.
According to the analysis of related databases, 101597-25-5, the application of this compound in the production field has become more and more popular.
Reference:
Article; Toth, Krisztian; Hoefner, Georg; Wanner, Klaus T.; Bioorganic and Medicinal Chemistry; vol. 26; 22; (2018); p. 5944 – 5961;,
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