With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.107859-98-3, name is Ethyl 3-(4-(hydroxymethyl)phenyl)propanoate, molecular formula is C12H16O3, molecular weight is 208.25, as common compound, the synthetic route is as follows.SDS of cas: 107859-98-3
Example 40 Ethyl 3-{4-[(methoxymethoxy)methyl]phenyl}propanoate A tetrahydrofuran solution (16 mL) of the compound (1.64 g) as produced in Example 2 was admixed with triethylamine (1.6 mL) and chloromethylmethylether (0.71 mL), followed by stirring at room temperature for one day. The reaction mixture was diluted with ethyl acetate, and the organic layer was washed with water and an aqueous saturated sodium chloride solution, dried over anhydrous sodium sulfate and concentrated. The resultant residue was purified on a silica gel column chromatography (n-hexane:ethyl acetate = 4:1) to give the subject title compound (1.47 g) showing the below-described physico-chemical values. TLC: Rf 0.43 (n-hexane:ethyl acetate = 3:1); 1H-NMR (CDCl3): d 1.24, 2.57-2.65, 2.95, 3.41, 4.13, 4.56, 4.70, 7.19, 7.28.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,107859-98-3, Ethyl 3-(4-(hydroxymethyl)phenyl)propanoate, and friends who are interested can also refer to it.
Reference:
Patent; ONO PHARMACEUTICAL CO., LTD.; EP1785421; (2007); A1;,
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