Related Products of 440-60-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 440-60-8, name is (Perfluorophenyl)methanol, molecular formula is C7H3F5O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
At 100mL2.95g (25mmol) of 2,3,4,5,6-pentafluorobenzyl alcohol was added to the three-necked flask.Triethylamine 2.5g,Toluene 40mL,Slow dropCis-2,2-dimethyl-3-(E/Z-2-chloropropenyl)cyclopropanecarboxylic acid chloride 6g (29mmol),The reaction was carried out at room temperature for 4 hours.The organic phase is sequentially 20mL5% sodium hydroxide solution,Wash with 5% hydrochloric acid solution and saturated sodium chloride solution, dry,After desolvation, a pale yellow viscous liquid is obtained.After column chromatography (petroleum ether / ethyl acetate = 20/1), 9.0 g of pale yellow liquid was obtained.The yield was 96%.
According to the analysis of related databases, 440-60-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Mt. Huang College; Han Bingbing; Zheng Zubiao; (15 pag.)CN109776327; (2019); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts