Reference of 29683-23-6 , The common heterocyclic compound, 29683-23-6, name is Tetrahydro-2H-thiopyran-4-ol, molecular formula is C5H10OS, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
The compound obtained in (80 mg, 0.28 mmol), tetrahydro-2H-thiopyran-4-ol (33.1 mg, 0.28 mmol) and triphenylphosphine (110.2 mg, 0.42 mmol) were dissolved in THF (2.5 mL), which was then slowly added with diethyl azodicarboxylate (DEAD, 191 muL, 0.42 mmol) and stirred at room temperature for 19 hours. The resulting mixture was concentrated and purified by silica gel chromatography to obtain the title compound (white solid, 33.7 mg, 31% yield). 1H NMR (300 MHz, CDCl3) delta 8.02 (d, 1H), 7.97 (dd, 1H), 7.18 (d, 1H), 6.79 (d, 1H), 6.67 (d, 1H), 4.50 – 4.38 (m, 3H), 3.91 (s, 3H), 3.00 – 2.92 (m, 2H), 2.87 – 2.76 (m, 1H), 2.63 – 2.47 (m, 3H), 2.36 (s, 3H), 2.27 – 2.17 (m, 2H), 2.12 – 2.01 (m, 2H)
The synthetic route of 29683-23-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SK Chemicals Co., Ltd.; LEE, Ju Young; LEE, Jeong A; AHN, Jaeseung; RYU, Je Ho; HAN, Min-Young; YOO, Taekyung; SA, Joon Ho; KIM, Jae-Sun; (297 pag.)EP2963027; (2016); A1;,
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