Month: June 2021

Application of 124-68-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 124-68-5, name is 2-Amino-2-methyl-1-propanol, molecular formula is C4H11NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: Fe(OTf)3 (1 mol%) was added to a magnetically stirred mixture of anamine (1 mmol) and Boc2O (1 mmol) at room temperature. The mixturewas stirred until completion of the reaction (TLC), then diluted withEtOAc and washed with water. The organic layer was dried overanhydrous MgSO4, then the solvent was distillated off under vacuum toyield the highly pure N-Boc derivatives

According to the analysis of related databases, 124-68-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Feng, Chengliang; Chu, Ningning; Zhang, Shuguang; Cai, Jin; Chen, Junqing; Hu, Huayou; Ji, Min; Journal of Chemical Research; vol. 37; 12; (2013); p. 757 – 760;,
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Adding a certain compound to certain chemical reactions, such as: 75853-18-8, 2,3-Difluorobenzyl alcohol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 2,3-Difluorobenzyl alcohol, blongs to alcohols-buliding-blocks compound. Recommanded Product: 2,3-Difluorobenzyl alcohol

Solid NaH (17 mg, 0.7 mmol, 7 eq. ) was added to a stirred solution of 2, 3-difluorobenzyl alcohol (0.10 g, 0.7 mmol, 7 eq. ) in dry benzene (5 mL) at 0 °C The solution was allowed to reach RT over 15 min. The product from step (a) (45 mg, 0.1 mmol, 1 eq. ) was added as a solid and the mixture was heated to reflux for 1 h. After cooling to RT, the reaction was quenched by addition of saturated aqueous NH4C1 (1 mL). The mixture was partitioned between EtOAc (10 ML) and water (10 mL). The organic phase was separated, dried over NA2S04 and evaporated. The oily residue was purified by preparative HPLC to give the title compound as an off-white solid (4.5 mg, 11 percent yield). IH NMR (CDCl3) 8 9.80-9. 20 (br s, 1H), 7.80 (s, 1H), 7.69-7. 29 (m, 3H), 6.50 (m, 1H), 5.49 (s, 2H), 4.41 (m, 1H), 3.78 (dd, 1H), 3.64 (dd, 1H), 1. 68-1. 48 (m, 3H), 0.95 (d, 3H), 0.91 (d, 3H); MS (EST) 7N/Z 406 [M+H].

The synthetic route of 75853-18-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASTRAZENECA AB; WO2005/33115; (2005); A1;,
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Reference of 34957-73-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.34957-73-8, name is Methyl 9-hydroxynonanoate, molecular formula is C10H20O3, molecular weight is 188.26, as common compound, the synthetic route is as follows.

Methyl 9-hydroxydecanoate (37.6 g, 0.2 mol) and MnO2 (17.4 g, 0.2 mol) were placed in a reaction kettle, 200 ml of ethyl acetate was added, stirring was started, 180 rpm, temperature 50 ° C, real-time monitoring The reaction was carried out, and after 8 h, it was cooled to room temperature, filtered, and the solvent was evaporated under reduced pressure to give 35.3 g of white solid product

Statistics shows that 34957-73-8 is playing an increasingly important role. we look forward to future research findings about Methyl 9-hydroxynonanoate.

Reference:
Patent; Beijing Xuyang Technology Co., Ltd.; Gao Xingdong; Du Chunhua; Pan Xiaojun; Wang Penghui; (11 pag.)CN109593045; (2019); A;,
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Application of 110-73-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 110-73-6, name is 2-(Ethylamino)ethanol, molecular formula is C4H11NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: A mixture of compound 3a or 3b (1 mmol),benzene (50 ml), Et3N (1 ml) and morpholine (1 ml) was stirred for 5 h at80C. The solvents were evaporated in vacuo and the residues werechromatographed on a column with Al2O3 (hexane-diethyl ether, 3 :1) toafford products 8a or 8b, respectively

According to the analysis of related databases, 110-73-6, the application of this compound in the production field has become more and more popular.

Reference:
Article; Sanchez Garcia, Jessica J.; Flores-Alamo, Marcos; Chirinos Flores, Denis E.; Klimova, Elena I.; Mendeleev Communications; vol. 27; 1; (2017); p. 26 – 28;,
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Electric Literature of 3513-81-3, Adding some certain compound to certain chemical reactions, such as: 3513-81-3, name is 2-Methylenepropane-1,3-diol,molecular formula is C4H8O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3513-81-3.

2-Methylene-propane-1,3-diol (2.2 g; 24.96 mmol) and dibutyltin oxide (6.85 g; 27.96 mmol) were refluxed in chloroform/methanol (100 ml 10: 1) for 24 h to obtain a clear solution. The solvent was removed under reduced pressure to give the stannoxane derivative as a white solid. Cesium fluoride (7.25 g; 47.7 mmol) was added and the mixture was dried under high vacuum. To this reaction mixture, DMF (20 ml) and benzyl bromide (3.27 ml ; 27.5 mmol) were added and the reaction mixture was stirred for 24 h at 25 °C. After that, the reaction mixture was heated at 50 °C for 1 h. The mixture is cooled to 25 °C and diluted with ethyl acetate (100 ml) and water (2 ml). The reaction mixture is stirred vigorously for 30 min and then filtered through a pad of celite to remove dibutyltin oxide. The filtrate was washed with water and then with brine, dried over Na2SO4 and the solvent was removed under reduced pressure. The crude product was purified by silica gel column chromatography eluting with 20 percent ethyl acetate/hexane to yield 2.6 g (60percent) compound 71a) as oil. 1H-NMR (CDCl3) : delta 7.36-7.28 (m, 5H), 5.20 (s, 1H), 5.15 (s, 1H), 4.51 (s, 2H), 4.19 (s, 2H), 4.10 (s, 2H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 3513-81-3, 2-Methylenepropane-1,3-diol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; WO2005/92881; (2005); A1;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2867-59-6, name is 3-Aminobutan-1-ol, molecular formula is C4H11NO, molecular weight is 89.14, as common compound, the synthetic route is as follows.Application In Synthesis of 3-Aminobutan-1-ol

in a microwave-tube, ethyl 2-[benzyloxycarbonyl(2-oxoethyi)amino]acetate (330 mg, 1 .18 mmol) was diluted in DCM (8 ml), then (+/-)-3-aminobutan-1-ol (1 16 mg, 1.24 mmol) and acetic acid (39 muIota, 673 prnol) were added to give a colorless solution. The reaction mixture was submitted to microwave heating for 1.5 h at 140 C. The reaction mixture was concentrated in vacuo and the residue was purified by flash chromatography (silica gel, 0% to 50% EtOAc in heptane) to give the title compound (183 mg, 51 %) as a colorless oil. The relative stereochemistry of the product was unambiguously assigned by NOESY NMR experiments. (1085) MS (ESI, m/z): 305.2 [(M+H)+].

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2867-59-6, 3-Aminobutan-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; SAVIRA PHARMACEUTICALS GMBH; EUROPEAN MOLECULAR BIOLOGY LABORATORY; LERNER, Christian; KREIS, Lukas; HILPERT, Hans; (268 pag.)WO2017/158151; (2017); A1;,
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Synthetic Route of 4654-39-1, Adding some certain compound to certain chemical reactions, such as: 4654-39-1, name is 2-(4-Bromophenyl)ethanol,molecular formula is C8H9BrO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4654-39-1.

A solution of 2-(4-bromophenyl)ethanol (4.43 g, 0.0220 mol) dissolved in CH2Cl2 (50 mL) was cooled to 0C. Next, PPh3 (6.92 g, 0.0264 mol) was added, followed by NBS (4.70 g, 0.0264 mol), and vigorous effervescence in a yellow solution was observed. The mixture was allowed to stir at 0C for 60 minutes. After this time, the yellow solution was treated with saturated sodium bicarbonate solution (20 mL). The deep, dark blue organic layer was separated, and the aqueous layer was extracted with CH2Cl2 (2 × 20 mL). The organic layers were combined and then the solvent was removed under reduced pressure to yield a deep, dark blue oil. The oil was purified on a column of silica (~1.5 cm × 20 cm) using EtOAc/hexanes (1:10) as an eluent and collecting the first nearly colourless fraction. Removal of the volatiles under reduced pressure yielded a very pale orange liquid. Yield: 5.38 g (93%). 1H NMR (500 MHz, 22C, CDCl3): 7.43 (d, 2H, 2JHH = 8 Hz, Ar), 7.08 (d, 2H, 2JHH = 8 Hz, Ar), 3.53 (t, 2H, 3JHH = 7 Hz, -CH2CH2-), 3.11 (t, 2H, 3JHH = 7 Hz, -CH2CH2-).

According to the analysis of related databases, 4654-39-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Tassone, Joseph P.; Mawhinney, Robert C.; Spivak, Gregory J.; Journal of Organometallic Chemistry; vol. 776; (2015); p. 153 – 156;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.455-01-6, name is 2-(3-(Trifluoromethyl)phenyl)ethanol, molecular formula is C9H9F3O, molecular weight is 190.1624, as common compound, the synthetic route is as follows.SDS of cas: 455-01-6

General procedure: DIAD (0.65mL, 3.31mmol) was added dropwise to 12a or 12b (500mg, 2.21mmol), PPh3 (869mg, 3.31mmol) and appropriate alcohol [2-phenylethanol (0.27mL, 2.21mmol, 2e; or 0.17mL, 1.46mmol, 2k), 2-(3-methoxyphenyl)ethanol (0.31mL, 2.21mmol, 2f; 0.20mL, 1.46mmol, 2l), or 2-(3-trifluoromethylphenyl)ethanol (0.33mL, 2.21mmol, 2g and 2m] in THF (10mL), and the mixture was stirred for 18h. Drying, evaporation and chromatography (PE/EtOAc 20:1) gave the esters 2e-g, k-m. Spectroscopic data for these compounds are given in the Supporting information.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,455-01-6, 2-(3-(Trifluoromethyl)phenyl)ethanol, and friends who are interested can also refer to it.

Reference:
Article; Yevglevskis, Maksims; Nathubhai, Amit; Wadda, Katty; Lee, Guat L.; Al-Rawi, Suzanne; Jiao, Tingying; Mitchell, Paul J.; James, Tony D.; Threadgill, Michael D.; Woodman, Timothy J.; Lloyd, Matthew D.; Bioorganic Chemistry; vol. 92; (2019);,
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Application of 454-91-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 454-91-1, name is 1-[3-(Trifluoromethyl)phenyl]ethanol, molecular formula is C9H9F3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

0.200 g (0.6 mmol) of (3R)-4-(4-toluenesulfonyl)thiomorpholine-3-carboxylic acid, 0.190 g (1.0 mmol) of 1-methyl-1-(3-trifluoromethylphenyl)-methanol, 0.088 g (0.33 mmol) of CAS, 0.227 g (1.2 mmol) of DCC and 0.04 g (0.33 mmol) of DMAP were dissolved in 15 mL of CH2Cl2. The mixture was stirred for 24 h at room temperature. The solid was filtrated and the solvent was evaporated. The residual was dissolved in a suitable amount of ethyl acetate (20 ml) and then the mixture was filtered to remove insoluble substance. The ethyl acetate was added to 60 ml and then the liquid was washed with 10% NaHCO3 solution, saturated NaCl solution and dried over Na2SO4. After the drying agent was removed and part of ethyl acetate was evaporated, the crude product was purified by flash column chromatography (eluent: ethyl acetate_cyclohexane=1:9) to obtain the product as a oil (0.13 g).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 454-91-1, 1-[3-(Trifluoromethyl)phenyl]ethanol.

Reference:
Patent; Li, Song; Nie, Aihua; Shen, Beifen; Wang, Lili; Pei, Wuhong; Xiao, Junhai; Yang, Songcheng; Yun, Liuhong; Liu, Hongying; Shu, Cuiling; Wang, Hongxia; Rao, Zihe; US2005/130958; (2005); A1;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.558-42-9, name is 1-Chloro-2-methyl-2-propanol, molecular formula is C4H9ClO, molecular weight is 108.5667, as common compound, the synthetic route is as follows.Recommanded Product: 558-42-9

2,2-Dimethylmorpholine hydrochloride 1-Chloro-2-methyl-2-propanol (135 ml) was added dropwise over 10 min to stirred 2-aminoethanol (400 ml) at 10° C. under nitrogen. The cooling bath was then removed and stirring was continued at room temperature for 48 h. A solution of sodium hydroxide (48.8 g) in methanol (440 ml) was added and the resulting white suspension was stirred for 10 min. The mixture was filtered through a pad of kieselguhr and the filtrate was concentrated under reduced pressure. The residual oil was distilled in vacuo to give 1-[(2-hydroxyethyl)amino]-2-methyl-2-propanol (133 g).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,558-42-9, 1-Chloro-2-methyl-2-propanol, and friends who are interested can also refer to it.

Reference:
Patent; Akzo Nobel N.V.; US5593983; (1997); A;,
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