Month: May 2021

Related Products of 702-82-9, Adding some certain compound to certain chemical reactions, such as: 702-82-9, name is 3-Aminoadamantan-1-ol,molecular formula is C10H17NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 702-82-9.

27.6 g (0.30 mol, 1.5 eq) of glyoxylic acid monohydrate,3-amino-1-adamantanol 33.5 g (0.20 mol, 1.0 eq),38.8 g (0.30 mol, 1.5 eq) of diisopropylethylamine and 250 g of tetrahydrofuran were placed in the reaction flask.51.1 g (0.50 mol, 2.5 eq) of acetic anhydride was added dropwise.Heat and reflux for 2 hours.The remaining amount of controlled raw materials in HPLC is less than 1%.Add 50g of water and stir for 30 minutes.Layered,The aqueous layer was extracted once with 50 g of dichloromethane.The organic layer was concentrated under reduced pressure to give a white solid.Compound II 42.8g,The yield is 96.1%.Purity 96.6%

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 702-82-9, 3-Aminoadamantan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Dalian Zhengbang Information Advisory Co., Ltd.; Gao Feng; Xie Nan; (7 pag.)CN108503571; (2018); A;,
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Adding a certain compound to certain chemical reactions, such as: 2425-41-4, (2-Phenyl-1,3-dioxane-5,5-diyl)dimethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: (2-Phenyl-1,3-dioxane-5,5-diyl)dimethanol, blongs to alcohols-buliding-blocks compound. name: (2-Phenyl-1,3-dioxane-5,5-diyl)dimethanol

The monobenzalpentaerythritol (5.00 g, 22.3 mmol), (3.5) 12G1-C02H (4b) (24.07 g, 49.05 mmol), and DPTS (5.90 g, 22.3 mmol) were dissolved in anhydrous CH2C12 (120 mL). DCC (1 1.96 g, 57.97 mmol) dissolved in anhydrous CH2C12 (20 mL) was added and the reaction was stirred for 12 h. at room temperature under nitrogen atmosphere. After the reaction was complete, the mixture was diluted, filtered, and rinsed with Et20. The solvent was removed and the crude product was purified by column chromatography (Si02, 5% Et20:hexane) and followed by precipitation in MeOH to give a white solid as a product: 25.29 g (97%). XH NMR (500 MHz, CDC13) delta 7.55 – 7.46 (m, 2H, PhH-3, 5), 7.41 – 7.34 (m, 3Eta, PhH-2, 4, 6), 7.12 (d, J= 2.3 Hz, 2H, ArH-2, 6), 7.1 1 (d, J= 2.2 Hz, 2H, ArH-2′, 6′), 6.64 (t, J= 2.2 Hz, 1H, ArH-4), 6.62 (t, J= 2.2 Hz, 1H, ArH-4′), 5.52 (s, 1Eta, CH-acetal), 4.82 (s, 2Eta, ArC02CH2), 4.33 (d, J= 11.8 Hz, 2H, 20CHaHb-ring), 4.26 (s, 2H, ArC02CH2), 4.03 (d, J= 11.8 Hz, 2H, 20CHaHb-ring), 3.98 – 3.90 (m, 8Eta, 4ArOCH2), 1.81 – 1.73 (m, 8Eta, 4ArOCH2CH2), 1.48 – 1.40 (m, 8Eta, 4ArOCH2CH2CH2), 1.26 (m, 64Eta, 4(CH2)8CH3), 0.88 (t, J= 6.9 Hz, 12H, 4CH3). 13C NMR (126 MHz, CDC13) delta 166.3 (C=0), 166.2 (C=0′), 160.4 (ArC-3, 5), 160.3 (ArC-3 ‘, 5’), 137.8 (PhC-1), 131.7 (PhC-3, 5), 131.2 (PhC-4), 129.4 (PhC-2, 6), 128.5 (ArC-1), 126.3 (ArC-1 ‘), 107.89 (ArC-2, 6), 107.85 (ArC-2′, 6′), 106.81 (ArC-4), 106.5 (ArC- 4′), 102.4 (CH-acetal), 69.9 (OC-ring), 68.52 (ArOCH2), 68.49 (ArOCH2′), 64.2 (ArC02CH2), 63.5 (ArC02CH2’), 38.0 (C(CH20)4), 32.1 (CH2CH2CH3), 29.82, 29.79, 29.76, 29.73, 29.6, 29.5, 29.3, 26.2 (ArOCH2CH2CH2), 22.8 (CH2CH3), 14.3 (CH3). The spectroscopic data of 16b are in agreement with those previously reported.

The synthetic route of 2425-41-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PERCEC, Virgil; WO2014/190024; (2014); A1;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.4719-04-4, name is 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol, molecular formula is C9H21N3O3, molecular weight is 219.2813, as common compound, the synthetic route is as follows.Computed Properties of C9H21N3O3

To 50.0 g(0.228 mol) of hexahydrotriazine (I) was added undervigorous agitation at 0C 16.14 g (0.114 mol) of P2O5until a homogeneous mass was formed. The resultingmixture was heated to 80C for 1 h. A 66.0-g (96%) portionof a light yellow viscous fl uid was obtained. Found,%: C 36.18, H 7.38, N 14.21. C9H22N3O6. Calculated,%: C 36.12, H 7.41, N 14.04, , 10.35.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,4719-04-4, 2,2′,2”-(1,3,5-Triazinane-1,3,5-triyl)triethanol, and friends who are interested can also refer to it.

Reference:
Article; Ishmiyarov; Rakhimova; Latypova; Abdullin; Voloshin; Dokichev; Russian Journal of Applied Chemistry; vol. 88; 7; (2015); p. 1174 – 1177; Zh. Prikl. Khim. (S.-Peterburg, Russ. Fed.); vol. 88; 7; (2015); p. 1083 – 1086,4;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 17100-58-2, name is (4-Bromo-2-methylphenyl)methanol. A new synthetic method of this compound is introduced below., Recommanded Product: 17100-58-2

[0653j To a solution of (4-bromo-2-methylphenyl)methanol (1.3 g, 6.7 mmol) in CH2C12 (50 mL) was added PBr3 (0.95 mL, 10 mmol) at 0 C. The mixture was stirred at rt for 1 h, quenched with ice-water (50 mL) and the pH value was adjusted to 7.0 with 50% aqueous NaOH solution. The mixture was extracted with EtOAc (100 mL x 2) and the combined organic layers were washed with water (50 mL), dried (Na2SO4) and concentrated in vacuo to give 4-bromo-1- (bromomethyl)-2-methylbenzene (1.56 g, yield: 89%) as a white solid which was used in next step without further purification.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 17100-58-2, (4-Bromo-2-methylphenyl)methanol.

Reference:
Patent; BIOGEN IDEC MA INC.; SUNESIS PHARMACEUTICALS, INC.; HOPKINS, Brian, T.; MA, Bin; CHAN, Timothy, Raymond; SUN, Lihong; ZHANG, Lei; KUMARAVEL, Gnanasambandam; LYSSIKATOS, Joseph, P.; KOCH, Kevin; MIAO, Hua; WO2015/89337; (2015); A1;,
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Synthetic Route of 59854-12-5 ,Some common heterocyclic compound, 59854-12-5, molecular formula is C8H16O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of tert-butyl-4-hydroxybutyrate (24, 100 mg, 0.62 mmol) in EtOAc (5 mL) was added CDI (101 mg, 0.62 mmol) and the reaction mixture was stirred for 3 h. Amine hydrochloride 20 (285 mg, 0.62 mmol) was added to the reaction mixture and the reaction was refluxed for 22 h. Upon cooling to rt the solvent was evaporated and the resultant residue was purified by column chromatography (silica-gel, gradient 10-20% EtOAc in petroleum ether) to afford impure ter/-butylester 25 (140 mg) as yellow oil: 1H NMR (CDCl3, 400 MHz) delta 8.36 (d , J = 8.8 Hz, 2H), 7.96 (d, J= 8.8 Hz, 2H), 7.34-7.22 (m, 5H), 4.77-4.76 (m, IH), 4.03-3.97 (m, 2H), 3.85-3.82 (m, IH), 3.20-3.17 (m, 2H), 3.02-2.87 (m, 2H), 2.38-2.34 (m, 2H), 2.24-2.18 (m, 2H), 1.89-1.82 (m, 3H), 1.46 (s, 9H), 0.91-0.87 (m, 6H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,59854-12-5, its application will become more common.

Reference:
Patent; AMPLYX PHARMACEUTICALS, INC.; MUTZ, Mitchell; BARR, Kenneth, J.; GESTWICKI, Jason; WO2010/77317; (2010); A2;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 16297-94-2, name is 3-(3-Methyl-3H-diazirin-3-yl)propan-1-ol. This compound has unique chemical properties. The synthetic route is as follows. category: alcohols-buliding-blocks

Intermediate 1 was dissolved with 40 mL of dichloromethane, then 3 mL of triethylamine was added.Then, p-toluenesulfonyl chloride (2.86 g, 15 mmol) was slowly added to the reaction solution.The reaction was stirred at room temperature overnight. After the reaction was completed, 1N HCl was added to the reaction solution. The organic phase is separated and the aqueous phase is extracted with dichloromethane. The combined organic phases were washed first with 1 N HCl and then with 1 N NaOH.Dry over anhydrous sodium sulfate and concentrate.The product was purified by silica gel column to give Intermediate 2 (2.2 g, yield 82%).

With the rapid development of chemical substances, we look forward to future research findings about 16297-94-2.

Reference:
Patent; Peking University; Zhou Demin; Si Longlong; Zhang Ziwei; Han Xu; Meng Kun; Zhang Bo; Xiao Sulong; Zhang Lihe; Zhou Xueying; (24 pag.)CN107304221; (2017); A;,
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Adding a certain compound to certain chemical reactions, such as: 495-76-1, Benzo[d][1,3]dioxol-5-ylmethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of Benzo[d][1,3]dioxol-5-ylmethanol, blongs to alcohols-buliding-blocks compound. Quality Control of Benzo[d][1,3]dioxol-5-ylmethanol

General procedure: General procedure for preparation of benzyl bromides from benzaldehydes: To a stirring solution of aldehyde (1.0 equiv) in methanol (0.2 M) was added sodium borohydride (2.0 equiv.). The resulting solution was stirred at RT for 30-60 mins, until no precipitate was evident in solution and flask was cool to the touch. Solvent was removed in vacuo and dichloromethane introduced. Organic layer was washed using water, dried over sodium sulfate, filtered and solvent removed in vacuo to yield crudebenzyl alcohol, which was used without further purification. To a stirring solution of benzyl alcohol (1.0 equiv.) in dry dichloromethane (0.1 M) at 0 C was added phosphorus tribromide (1.1 equiv.). The reaction solution was stirred at 0 00 for 30 mins, quenched with water, transferred to a separating funnel and the organic layer washed with water. Combined organic layers were dried over sodium sulfate, filteredand solvent removed in vacuo to yield crude benzyl bromide, which was used without purification in catalytic Wittig reactions. o Br 5-(Bromomethyl)-1,3-benzodioxole was prepared inaccordance with the general procedure. 1,3-Benzodioxol-5-o – ylmethanol was prepared in 88% yield (2.68 g, 17.6 mmol) fromthe reaction of piperonal (3.00 g, 20 mmol, 1 .0 equiv.) and sodium borohydride (1 .51 g,40 mmol, 2.0 equiv.). Upon reaction with phosphorus tribromide (1.82 mL, 19.4 mmol,1.1 equiv.), 5-(bromometh/l)-1,3-benzodioxole was obtained as a white solid in 85%yield (3.54 g, 16.5 mmol). H NMR (400 MHz, CDCI3) 6: 3.84 (s, 3H), 3.87 (s, 6H), 4.47(s, 2H), 6.62 (s, 2H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,495-76-1, Benzo[d][1,3]dioxol-5-ylmethanol, and friends who are interested can also refer to it.

Reference:
Patent; DUBLIN CITY UNIVERSITY; O’BRIEN, Christopher; WO2014/140353; (2014); A1;,
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Adding a certain compound to certain chemical reactions, such as: 104-38-1, 1,4-Bis(2-hydroxyethoxy)benzene, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: alcohols-buliding-blocks, blongs to alcohols-buliding-blocks compound. category: alcohols-buliding-blocks

EXAMPLE 125 Sulfamic acid 2-[4-[2-[(aminosulfonyl)oxy]ethoxy]phenoxy]ethyl ester A mixture of 19.8 g (0.1 mole) of hydroquinone bis (2-hydroxyethyl)ether (98%, Aldrich) and 41.4 g (0.41 mole) of triethylamine in 350 ml of acetonitrile was added to a cooled (acetone-ice bath, temp?15 C.) solution of 130 ml of sulfamoyl chloride solution (3.14 M solution in acetonitrile) and 100 ml of acetonitrile. The mixture was mechanically stirred at ambient temperature overnight. The solvent was evaporated under reduced pressure and the residue was partitioned between 400 ml of water and 800 ml of ethyl acetate. The aqueous layer was extracted with two 400 ml portions of ethyl acetate and the combined ethyl acetate extracts (1.61) were washed with two 400 ml portions of water, dried (magnesium sulfate) and the solvent evaporated under reduced pressure to give a viscous residue which was triturated with 100 ml of methylene chloride and let stand at ambient temperature for two days. The resulting solid was collected by filtration and then washed with water until the filtrate was neutral to pH paper and dried (air). The solid was recrystallized from acetonitrile to yield 9.9 g (29%) of a white solid containing a small amount of acetonitrile, mp 162-164 C. Analysis: Calculated for C10 H16 N2 O8 S2: C, 33.70; H, 4.53; N, 7.86. Found: C, 34.30; H, 4.62, N, 8.03.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,104-38-1, 1,4-Bis(2-hydroxyethoxy)benzene, and friends who are interested can also refer to it.

Reference:
Patent; A. H. Robins Co., Inc.; US5025031; (1991); A;,
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Application of 111-90-0 ,Some common heterocyclic compound, 111-90-0, molecular formula is C6H14O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Chloroformate solution was made by adding triphosgene (98.9 mg, 0.333 mmol) to a stirred solution of di(ethylene glycol) monoethyl ether (134.2 mg, 1 mmol) and dry triethylamine (101.2 mg, 0.139 mL, 1 mmol) in dry dichloromethane (2 mL) at 0 C. under an argon atmosphere, and stirred for 1 h at 0 C.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,111-90-0, its application will become more common.

Reference:
Patent; AllTranz Inc.; US2011/245288; (2011); A1;,
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Related Products of 616-29-5 ,Some common heterocyclic compound, 616-29-5, molecular formula is C3H10N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

The Schiff base ligand, H2L, N,N0-bis(salicyaldehydene)-1,3-diaminopropan-2-ol was synthesized in a reported literature [19].Salisaldehyde (0.244 g, 2 mmol) was heated under reflux with1,3-diaminopropan-2-ol (0.089 g, 1 mmol) in 30 ml dehydratedalcohol. After 10 h the reaction solution was evaporated underreduced pressure to yield a gummy mass, which was dried undervacuum and stored over CaCl2 for subsequent use. Yield, 0.278 g(82.8%). Anal. Calc. for C17H18N2O3 (H2L): C, 68.48; H, 6.08; N,9.39. Found: C, 68.40; H, 6.02; N, 9.35%. 1H NMR (CDCl3) d = 3.68(dd, J = 12.4, 6.8 Hz, 2H), 3.84 (dd, J = 12.4, 4.0 Hz, 2H), 4.23-4.25(m, 1H), 6.88 (t, J = 7.2 Hz, 2H), 6.96 (d, J = 8.4 Hz, 2H), 7.25 (dd,J = 7.6, 1.6 Hz, 2H), 7.32 (td, J = 8.8, 1.6 Hz, 2H), 8.36 (s, 2H) ppm.13C NMR d, 62.9, 70.2, 117.0, 118.5, 118.6, 131.5, 132.5, 161.1,167.3 ppm. IR (KBr, cm1): 1634, 1611 (vCN), 3412 (vOH), UV-Vis(kmax, nm): 221, 267, 316, 410 nm.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 616-29-5, 1,3-Diaminopropan-2-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Dey, Dhananjay; Kaur, Gurpreet; Patra, Moumita; Choudhury, Angshuman Roy; Kole, Niranjan; Biswas, Bhaskar; Inorganica Chimica Acta; vol. 421; (2014); p. 335 – 341;,
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