Month: May 2021

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5339-85-5, name is 2-(2-Aminophenyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 2-(2-Aminophenyl)ethanol

COMPARATIVE EXAMPLE 7 The first run procedures of Example 12 were repeated except that 0.15 g of “NDT-90” was used without K2 CO3 and reaction was continued for 9 hours. The conversion of 2-(o-aminophenyl)ethanol was 12.5% and the yield of indole was 10.8%.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 5339-85-5, 2-(2-Aminophenyl)ethanol.

Reference:
Patent; Research Association for Utilization of Light Oil; US4757152; (1988); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 75476-86-7, 6-Bromo-2,3-dihydro-1H-inden-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 75476-86-7, blongs to alcohols-buliding-blocks compound. SDS of cas: 75476-86-7

A solution of 6-bromo-indan-1-ol (1 mmol) and NEt3 (4 mmol) in dry THF (5 mL) was stirred at -15 C under argon. A solution of methanesulfonyl chloride (2 mmol) in dry THF (1 mL) was cooled to -78 C and then slowly added to the alcohol solution maintaining the temperature below 0 C. The reaction mixture was stirred for 2h at -15 C and then purged with dimethylamine gas (12 mmol). The reaction mixture was allowed to warm to room temperature and stirred overnight. Then, it was filtered to remove salts and solvent was evaporated. Crude was dissolved in CH2Cl2 and extracted with HCl 1 M (3x). The aqueous phase was basified with NaOH 6M to pH 8-9 and extracted with CH2Cl2. The combined organic extracts were dried over MgSO4 and concentrated to dryness. The crude was used in next step without further purification.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,75476-86-7, 6-Bromo-2,3-dihydro-1H-inden-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; Laboratorios del. Dr. Esteve, S.A.; EP2308849; (2011); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 431-38-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 431-38-9, name is 3-Amino-1,1,1-trifluoropropan-2-ol. This compound has unique chemical properties. The synthetic route is as follows.

A suspension of intermediate Int-21 (1.0 equiv.) and (0487) racemic-3- Amino- l,l,l-trifluoro-propan-2-ol (3.0 equiv.), and triethylamine (5.0 equiv) in 3: 1 dioxane/water (1.3 mL) was heated at 90 C for 12 hours, after which LC-MS analysis indicated that the conversion was complete. The reaction mixture was diluted with water and adjusted to pH 6-7 with 1.0 N aqueous hydrochloric acid solution, leading to the formation of an orange precipitate. The solid was filtered and dried. Purification of the crude solid was achieved by reverse phase HPLC utilizing a gradient of 10 to 40 % acetonitrile in water (modified by 0.1% trifluoroacetic acid) over 20min to afford racemic Compound 1-11 (57.4 mg, 48 % yield) as an off-white solid. 1H NMR: (500 MHz, CD3OD), d (ppm): 9.63 (s, 1 H), 8.61 (s, 1 H), 7.74 (s, 1 H), 7.30 – 7.33 (m, 1 H), 7.15 – 7.20 (m, 1 H), 6.97 – 7.01 (m, 2 H, overlapping shifts), 4.67 (s, 2 H), 4.28 – 4.32 (m, 1 H), 3.98 – 4.02 (m, 4 H, overlapping shifts), 3.86 – 3.91 (m, 1 H). MS ES+ m/z 464.2 [M+H]+

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 431-38-9, 3-Amino-1,1,1-trifluoropropan-2-ol.

Reference:
Patent; CYCLERION THERAPEUTICS, INC.; RENNIE, Glen, Robert; RENHOWE, Paul, Allan; NAKAI, Takashi; MERMERIAN, Ara; CUMBERBATCH, Helen; (99 pag.)WO2019/126354; (2019); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 4170-90-5, Mesitylmethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: Mesitylmethanol, blongs to alcohols-buliding-blocks compound. name: Mesitylmethanol

In the glove box, Mn(CO)5Br (0.005mmol),[(E)-2-(2-(1-(2-pyridyl)ethylidene)-indenyl)pyridin](0.006mmol),Add 1.0 mL of toluene, stir for two hours, add 2-methylquinoline 4 (2 mmol)2e (1mmol), after reacting at 135 C for 48 hours, the reaction was stopped, and the solvent was evaporated to dryness.Column chromatography ethyl acetate / petroleum ether (1:10),Trans-disubstituted olefin derivative 3ae. The product was a white solid in 80% yield.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,4170-90-5, Mesitylmethanol, and friends who are interested can also refer to it.

Reference:
Patent; Qingdao University of Science and Technology; Zhang Chunyan; (19 pag.)CN108250153; (2018); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 25574-11-2, 3-(4-Bromophenyl)propan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C9H11BrO, blongs to alcohols-buliding-blocks compound. Formula: C9H11BrO

To a solution of 3-(4-bromophenyl)propan-l-ol (22.8 g, 106 mmol, 1 equiv.) in THF (1.06 L) at -78C was added w-BuLi (1.6 M, 358 mL, 573 mmol, 5.4 equiv.) dropwise. After stirring at -78C for 5 hours, the temperature was allowed to reach -50C and isobutylene oxide (47.1 mL, 530 mmol, 5 equiv.) was added dropwise. After stirring at -50C for 30 min, boron trifluoride etherate (101 mL, 796 mmol, 7.5 equiv.) was added dropwise. After stirring at -50C for lh30, the reaction was quenched with a 10% w/w solution of Na/K tartrates and the mixture was allowed to reach room temperature overnight. It was extracted three times with ether, the combined organic extracts were dried over sodium sulfate and the solvent was evaporated. Lighter impurities were removed by bulb-to-bulb distillation (100-120C, 10 mbar) to afford 3-[4-(2-hydroxy-2- methylpropyl)phenyl]propanol as an oil (11.5 g, 52 % yield) that solidified upon standing. 1H NMR: 1.22 (s, 6H), 1.44 (s, 2H), 1.85-1.92 (m, 2H), 2.65-2.73 (m, 2H), 2.73 (s, 2H),3.67 (t, / = 6.4, 2H), 7.12-7.14 (m, 4H). 13C NMR: 140.0 (s), 135.2 (s), 130.5 (d, 2C), 128.3 (d, 2C), 70.8 (s), 62.3 (t), 49.3 (t), 34.2 (t), 31.7 (t), 29.2 (q, 2C).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,25574-11-2, 3-(4-Bromophenyl)propan-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; FIRMENICH SA; COULOMB, Julien; (28 pag.)WO2017/9175; (2017); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 612-16-8, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 612-16-8 as follows.

In the glove box, Mn(CO)5Br (0.005mmol), [(E)-2-(2-(1-(2-pyridyl)ethylidene)-indenyl)pyridinium](0.006 mmol),Add 1.0 mL of toluene, stir for two hours, add 2-methylquinoline 4 (2 mmol),2i (1 mmol), after reacting at 135 C for 48 hours, the reaction was stopped, and the solvent was evaporated to dryness.Column chromatography ethyl acetate / petroleum ether (1:10),Trans-disubstituted olefin derivative 3ai. The product was a white solid with a yield of 93%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,612-16-8, its application will become more common.

Reference:
Patent; Qingdao University of Science and Technology; Zhang Chunyan; (19 pag.)CN108250153; (2018); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 1462-03-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1462-03-9, name is 1-Methylcyclopentanol. A new synthetic method of this compound is introduced below.

1-methylcyclopentanol (2 mmol), catalytic amounts of the ionic liquid, and 1-2 mL of acetic acid were charged into an oven-dried Schlenk tube under nitrogen. The reaction mass was stirred for 15-20 minutes at r.t. before adding the selected nitrile (1 mmol). The reaction mass was stirred at the indicated temperature for the specified time (see Table 3). The progress of the reaction was monitored by TLC and GC-MS. After completion of reaction, the reaction mass was quenched with distilled water followed by neutralization with dilute NaHCO3 solution. The product was extracted with diethyl ether, dried over anhydrous MgSO4, and the ether layer was evaporated in vacuum. The resulting crude products were chromatographed with hexane-ethyl acetate mixture (80:20) to afford pure colorless solids.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1462-03-9, its application will become more common.

Reference:
Article; Kalkhambkar, Rajesh G.; Waters, Sarah N.; Laali, Kenneth K.; Tetrahedron Letters; vol. 52; 8; (2011); p. 867 – 871;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 7073-69-0 , The common heterocyclic compound, 7073-69-0, name is 2-(2-Bromophenyl)propan-2-ol, molecular formula is C9H11BrO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Step 2[00253] To a solution of n-BuLi (21.2ml, 0.053 mol) in anhydrous THF (160 mL) at – 78C under argon was slowly added a solution of 2-(2-bromophenyl)propan-2-ol (XCV) (0.0212 mol, 4.55 g) in anhydrous THF (50 mL) while maintaining the temperature below -65C. After addition was complete, the reaction mixture was stirred at -75C for 30 min. To this mixture was added in portions trimethyl borate (0.032mol, 3.3 g), and the reaction mixture was stirred at – 78C for 30 min and then at room temperature overnight. The mixture was cooled to 0C, carefully quenched with 1M aqueous HCl, and stirred at room temperature for 15 min. The mixture was acidified to pH 3 with 2M HCl and stirring was continued for 1 hour. The two phases were separated and the aqueous layer was extracted with EtOAc. The combined organic phases were dried over MgS04. The crude product was purified by silica gel chromatography using DCM followed by DCM/MeOH 300/1 to give 3,3-dimethylbenzo[c][l,2]oxaborol-l(3H)- ol (XCVI) as a light yellow oil (1.37 g; 8.5 mmol, 40% yield). 1H NMR (CDC13) delta ppm 1.54 (s, 6H), 7.25-7.29 (m, 1H), 7.33 (d, J=7Hz, 1H), 7.45 (td, J=7Hz, J=lHz, 1H), 7.68 (d, J=7Hz, 1H).

The synthetic route of 7073-69-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; REMPEX PHARMACEUTICALS, INC.; GLINKA, Tomasz; HIGUCHI, Robert; HECKER, Scott; EASTMAN, Brian; RODNY, Olga; WO2012/109164; (2012); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 6642-34-8, name is (6-Bromobenzo[d][1,3]dioxol-5-yl)methanol. This compound has unique chemical properties. The synthetic route is as follows. Formula: C8H7BrO3

To a stirred solution of (6-bromo-1,3-benzodioxol-5-yl)methanol (1.27 g, 5.50 mmol) in THF (45.0 ml.) was added n-BuLi (5.00 ml_, 2.0 M, 10.0 mmol) dropwise at -75 0C. The reaction mixture was stirred at -75 0C for 45 min followed by the addition of a solution of 1-pentyl-1/-/-indole-2,3-dione (1.00 g, 4.60 mmol) in THF (20.0 ml.) at -75 0C. The resulting mixture was stirred at ambient temperature for 12 hrs and quenched with ammonium chloride solution (5.00 ml_). More ethyl acetate and water were added and separated. The organic layer was concentrated in vacuo to dryness. The residue was subjected to column chromatography eluting with 50% EtOA?Hexanes to yield the title compound (0.29 g, 25%) as a solid: 1H NMR (300 MHz, CDCI3) delta 7.38-7.24 (m, 2H), 7.11 (t, 1 H), 6.91 (d, 1 H), 6.81 (s, 1 H), 6.43 (s, 1 H), 5.90-5.87 (m, 2H), 4.77 (dd, 2H), 3.75-3.56 (m, 2H), 1.75-1.58 (m, 2H), 1.26-1.35 (m, 2H), 0.89-0.83 (m, 3H); 13C NMR (75 MHz, CDCI3) delta 177.8, 147.4, 147.2, 142.8, 133.5, 132.2, 131.1 , 130.1 , 125.3, 123.8, 111.4, 109.2, 108.1 , 101.5, 79.5, 64.7, 40.4, 29.0, 26.8, 22.3, 13.9; MS (ES+) m/z 352.1 (M – 17).

With the rapid development of chemical substances, we look forward to future research findings about 6642-34-8.

Reference:
Patent; XENON PHARMACEUTICALS INC.; WO2006/113864; (2006); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 4728-12-5 ,Some common heterocyclic compound, 4728-12-5, molecular formula is C7H14O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

30.1.(2,2-dimethyl-1,3-dioxan-5-yl)methyl 4-methylbenzenesulfonateTo a solution of 1.5 g (10.26 mmol) of (2,2-dimethyl-1,3-dioxan-5-yl)methanol and 1.71 mL of Et3N in 15 mL of DCM, cooled to 0° C., are added 2.15 g (11.3 mmol) of tosyl chloride.The medium is allowed to warm to room temperature, and stirring is continued for 1 hour.The medium is taken up in 100 mL of DCM, washed successively with 0.1N HCl (2*20 mL) and brine (20 mL), dried over Na2SO4, concentrated under reduced pressure and then purified by chromatography on a column of silica gel, eluting with a 99/1 DCM/MeOH mixture.3 g of (2,2-dimethyl-1,3-dioxan-5-yl)methyl 4-methylbenzenesulfonate are obtained in the form of a colourless oil.Yield=97percent1H NMR, CDCl3, 400 MHz, delta (ppm): 7.8 (d, 2H); 7.3 (d, 2H); 4.1 (d, 2H); 3.9 (dd, 2H); 3.6 (dd, 2H); 2.4 (s, 3H); 1.9 (m, 1H); 1.4 (s, 3H); 1.2 (s, 3H)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4728-12-5, its application will become more common.

Reference:
Patent; SANOFI; US2011/294788; (2011); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts