Month: May 2021

Related Products of 349-75-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 349-75-7, name is (3-(Trifluoromethyl)phenyl)methanol. A new synthetic method of this compound is introduced below.

General procedure: To a solutionof a carboxylic acid in dry DMF (0.2±1.6 mL), CDI (2±2.2 equiv) was added and the mixturewas stirred at rt for 1 h under argon atmosphere. An alcohol (1.1±2 equiv), DBU (0.5±2 equiv)and DMAP (0.1 equiv) were subsequently added and the reaction mixture was microwave irradiatedat 50 C for 1 h. The reaction was quenched with ice water and extracted with EtOAc.The combined organic layers were washed with a saturated solution of NaHCO3 in water,brine and the solvent was evaporated under reduced pressure at 40 C. The crude residue waspurified by flash column chromatography with appropriate eluents and a gradient.3-(trifluoromethyl)benzyl 2-[(4-methoxyphenoxy)methyl]-5-methyl-6-[[3-(trifluoromethyl)benzyl]oxy]pyrimidine-4-carboxylate (21). General procedure IV was followed.Compound 16 (0.060 g, 0.13 mmol), dry DMF (0.2 mL), CDI (43 mg, 0.27 mmol, 2 equiv), 3-(trifluoromethyl)benzyl alcohol (36 muL, 0.27 mmol, 2 equiv), DBU (0.010 mL, 0.067 mmol, 0.5equiv), DMAP (1.6 mg, 0.013 mmol, 0.1 equiv). Flash chromatography eluents: cyclohexane(A), EtOAc (B); gradient: 6%45% B×10 CV. Compound 21 was isolated as a yellow oil (49mg, 0.081 mmol, 62% yield).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,349-75-7, (3-(Trifluoromethyl)phenyl)methanol, and friends who are interested can also refer to it.

Reference:
Article; Provenzani, Riccardo; Tarvainen, Ilari; Brandoli, Giulia; Lempinen, Antti; Artes, Sanna; Turku, Ainoleena; Jaentti, Maria Helena; Talman, Virpi; Yli-Kauhaluoma, Jari; Tuominen, Raimo K.; Boije af Gennaes, Gustav; PLoS ONE; vol. 13; 4; (2018);,
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Adding a certain compound to certain chemical reactions, such as: 186020-66-6, tert-Butyl 12-Hydroxy-4,7,10-trioxadodecanoate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 186020-66-6, blongs to alcohols-buliding-blocks compound. Quality Control of tert-Butyl 12-Hydroxy-4,7,10-trioxadodecanoate

Second Step tert-Butyl 3-[2-[2-[2-(4-methylphenyl)sulfonyloxyethoxy]ethoxy]ethoxy]propanoate tert-Butyl 3-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]propanoate (488 mg, 1.75 mmol) and triethylamine (532 mg, 5.26 mmol) were dissolved in dichloromethane (15 mL), and tosyl chloride (435 mg, 2.28 mmol) was added. After the mixture was stirred at room temperature for 17 hours, the reaction mixture was concentrated, and the resultant residue was purified by column chromatography on silica gel (hexane:ethyl acetate=1:2) to obtain the title compound (550 mg, 73%) as colorless clear oil. LCMS: m/z 450[M+H2O]+ HPLC retention time: 0.90 minutes (analysis condition SQD-FA05)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,186020-66-6, its application will become more common.

Reference:
Patent; CHUGAI SEIYAKU KABUSHIKI KAISHA; OHTAKE, Yoshihito; OKAMOTO, Naoki; ONO, Yoshiyuki; KASHIWAGI, Hirotaka; KIMBARA, Atsushi; HARADA, Takeo; HORI, Nobuyuki; MURATA, Yoshihisa; TACHIBANA, Kazutaka; TANAKA, Shota; NOMURA, Kenichi; IDE, Mitsuaki; MIZUGUCHI, Eisaku; ICHIDA, Yasuhiro; OHTOMO, Shuichi; HORIBA, Naoshi; (310 pag.)US2016/2251; (2016); A1;,
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Synthetic Route of 7073-69-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 7073-69-0, name is 2-(2-Bromophenyl)propan-2-ol. A new synthetic method of this compound is introduced below.

General procedure: Using diaryl acetylenesA 5-mL two-necked flask equipped with a stir bar was charged with [RhCl(cod)]2 (0.0125 mmol,6.16 mg), BINAP (0.0125 mmol, 7.78 mg), 1a-c (0.25 mmol), KI (0.25 mmol, 41.5 mg), and Na2CO3(1.0 mmol, 106.0 mg). The central neck of the flask was equipped with a reflux condenser havinga N2 gas-bag (2 L), which was connected by a three-way stopcock at its top, and a rubber septumwas inserted i n to the side neck. The flask was evacuated and backfilled with N2 (three times).Xylene (1.0 mL), 2a (0.75 mmol, 161.3 mg), and furfural (1.75 mmol, 168.2 mg), were then added.After degassing the reaction mixture three times by the freeze-pump-thaw method, the flask wasfilled with N2. The mixture was placed in an oil bath that had been preheated to 140 C for 20 h.After cooling to room temperature, the resulting solution was filtered through a pad of celite, andthe filtrate was concentrated in vacuo. The resulting crude product was purified by flash columnchromatography on silica-gel to afford 3aa-3ac.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,7073-69-0, 2-(2-Bromophenyl)propan-2-ol, and friends who are interested can also refer to it.

Reference:
Article; Furusawa, Takuma; Tanimoto, Hiroki; Nishiyama, Yasuhiro; Morimoto, Tsumoru; Kakiuchi, Kiyomi; Chemistry Letters; vol. 46; 7; (2017); p. 926 – 929;,
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Application of 229027-89-8, Adding some certain compound to certain chemical reactions, such as: 229027-89-8, name is 2-Bromo-4-fluorobenzyl Alcohol,molecular formula is C7H6BrFO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 229027-89-8.

A mixture of (2-bromo-4-fluorophenyl)methanol (250g, 1.22 mol) and 3,4-dihydro-2H-pyran (205 g, 2.44 mol) is dissolved in DCM (2000 mL). To this solution is added pyridinium p-toluenesulfonate (15g, 0.06 mol). The resulting solution is stirred overnight at rt and then treated with saturated NaHC03. After extraction with EtOAc, the organic layer is washed with water and brine, dried, concentrated and purified by column chromatography over silica gel to provide the product of this step (281 g, yield 80%) as colorless oil.

According to the analysis of related databases, 229027-89-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ELI LILLY AND COMPANY; ANACOR PHARMACEUTICALS INC.; AKAMA, Tsutomu; JARNAGIN, Kurt; PLATTNER, Jacob J.; PULLEY, Shon Roland; WHITE, William Hunter; ZHANG, Yong-Kang; ZHOU, Yasheen; WO2014/149793; (2014); A1;,
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Application of 63478-76-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 63478-76-2, name is 6-Heptyn-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

To a stirred solution of 6-heptyn-1-ol 812 (3.33 mL, 26.75 mmol) in CH2CI2 (80 mL) at r.t. was added imidazole (1.76 g, 27.01 mmol) and terf-butyldimethylsilyl chloride (4.07 g, 27.01 mmol). The reaction mixture was allowed to stir at r.t. for 24 h. The mixture was then diluted with Et24 and concentrated in vacuo. The crude product was purified by filtration through silica gel to give alkyne 813 (5.68 g, q uant.) as a colourless liquid . Alkyne 813 was used in subsequent synthetic steps without characterisation.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 63478-76-2, 6-Heptyn-1-ol.

Reference:
Patent; AUCKLAND UNISERVICES LIMITED; BRIMBLE, Margaret Anne; WILLIAMS, Geoffrey Martyn; DUNBAR, Peter Roderick; VERDON, Daniel; (184 pag.)WO2017/145097; (2017); A2;,
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Reference of 221285-25-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 221285-25-2, name is (2-Amino-6-fluorophenyl)methanol. A new synthetic method of this compound is introduced below.

N-(3-Fluoro-2-(hydroxymethyl)phenyl)pivalamide; Trimethylacetyl chloride (0.25 mL, 1.99 mmol) was added to a solution of (2-amino-6-fluorophenyl)methanol (268 mg, 1.90 mmol) in CH2Cl2 (10 mL) at 0° C., followed by the addition of DIEA (1.0 mL, 5.7 mmol). The mixture was stirred for 1 hr, followed by normal aqueous work-up to afford the expected crude product, N-(3-fluoro-2-(hydroxymethyl)phenyl)pivalamide, as a colorless oil(415 mg, 97percent yield), which was used directly in the next step; 1H NMR (400 MHz, CDCl3) delta ppm 1.29 (s, 9 H), 2.64 (s, 1 H), 4.78 (d, J=4.78 Hz, 2 H), 6.75-6.84 (m, 1 H), 7.23 (td, J=8.62, 5.92 Hz, 1 H), 7.86 (d, J=8.31 Hz, 1 H), 8.97 (s, 1 H); Mass spec. 226.11 (MH+), Calc. for C12H16FNO2 225.12.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,221285-25-2, (2-Amino-6-fluorophenyl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; Bristol-Myers Squibb Company; US2007/259850; (2007); A1;,
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Synthetic Route of 112-27-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 112-27-6, name is 2,2′-(Ethane-1,2-diylbis(oxy))diethanol. This compound has unique chemical properties. The synthetic route is as follows.

Compound 222 is commercially available. 44.48 ml (0.33 mol) of compound 222 was treated with tosyl chloride (25.39 g, 0.13 mol) in pyridine (500mL) for 16 hours. The reaction was then evaporated to an oil, dissolved in EtOAc and washed with water, sat. NaHCO3, brine, and dried over Na2SO4. The ethyl acetate was concentrated to dryness and purified by column chromatography, eluted with EtOAc/hexanes (1:1) followed by 10% methanol in CH2Cl2 to give compound 223 as a colorless oil. LCMS and NMR were consistent with the structure

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 112-27-6, 2,2′-(Ethane-1,2-diylbis(oxy))diethanol.

Reference:
Patent; ISIS PHARMACEUTICALS, INC.; PRAKASH, Thazha, P.; SETH, Punit, P.; SWAYZE, Eric, E.; GROSSMAN, Tamar, R.; MCCALEB, Michael, L.; WATT, Andrew, T.; FREIER, Susan, M.; WO2015/168635; (2015); A2;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 20605-01-0, name is Diethyl 2,2-bis(hydroxymethyl)malonate, the common compound, a new synthetic route is introduced below. Formula: C9H16O6

General procedure: A solution of diethyl 2,2-bis(hydroxymethyl) malonate(12 mmol), 1 (10 mmol) and sulfonated carbon(1.0 g) were heated to reflux in a mixture of N,N-dimethylformamide(10 mL) and cyclohexane (6 mL)under stirring for 3 h. After cooling to room temperature,the solution was filtered and the solvent was removed in vacuo, the residue was dissolved in EtOAc (15 mL),washed with saturated brine (10 mL × 2) and water(10 mL×2), dried over anhydrous Na2SO4. The solventwas filtered and concentrated to give 2a-2d as colorless oil.

The synthetic route of 20605-01-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Yuan, Lin; Li, Zhong Yan; Zhang, Min; Yuan, Xian You; Zhu, Xiao Qing; Journal of Nanoscience and Nanotechnology; vol. 17; 3; (2017); p. 2201 – 2205;,
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Application of 110-73-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 110-73-6, name is 2-(Ethylamino)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

Potassium carbonate (10.4 g, 75.4 mmol) and 2-(ethylamino)ethanol (6.72 g, 75.4 mmol) were added to a solution of 2-bromo-1-phenylethanone (5.00 g, 25.1 mmol) in acetonitrile (150 ml), and the mixture was stirred at RT overnight. The solids were then removed by filtration, and the filtrate was concentrated under reduced pressure to afford the crude title compound which was used in the next step without further purification. Yield: 5.00 g (85% purity, 82% yield). LC/MS [Method 3]: Rt = 0.44 min; MS (ESIpos): m/z = 208 [M+H]+. 1H-NMR (400 MHz, DMSO-d6): d [ppm] = 7.55-7.48 (m, 2H), 7.37-7.23 (m, 3H), 4.11-4.03 (m, 1H), 3.67-3.59 (m, 1H), 3.48-3.36 (m, 1H), 2.76-2.67 (m, 2H), 2.36-2.26 (m, 1H), 2.16-2.06 (m, 1H), 2.01 (d, 1H), 0.99 (t, 3H).

According to the analysis of related databases, 110-73-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; MUeLLER, Steffen; SCHOHE-LOOP, Rudolf; ORTEGA, HERNANDEZ, Nuria; SUeSSMEIER, Frank; JIMENEZ NUNEZ, Eloisa; BRUMBY, Thomas; LINDNER, Niels; GERDES, Christoph; POOK, Elisabeth; BUCHMUeLLER, Anja; GAUGAZ, Fabienne, Zdenka; LANG, Dieter; ZIMMERMANN, Stefanie; EHRMANN, Alexander, Helmut, Michael; GERISCH, Michael; LEHMANN, Lutz; TIMMERMANN, Andreas; SCHAeFER, Martina; SCHMIDT, Georg; SCHLEMMER, Karl-Heinz; FOLLMANN, Markus; KERSTEN, Elisabeth; WANG, Vivian; GAO, Xiang; WANG, Yafeng; (801 pag.)WO2019/219517; (2019); A1;,
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Reference of 144-19-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 144-19-4, name is 2,2,4-Trimethyl-1,3-pentanediol. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: EXAMPLE 7-1 Oxidation of 2,2-Dimethyl-5-phenylpentane-1,3-diol A sodium chlorite aqueous solution (81.0 mg, 0.717 mmol in H2O (0.4 ml)), and a sodium hypochlorite aqueous solution (0.0146 M, 0.16 ml) were separately and slowly dropped onto an acetonitrile (1.2 ml)-pH 6.8 phosphate buffer (1 M, 0.8 ml) of 2,2-dimethyl-5-phenylpentane-1,3-diol (49.7 mg, 0.239 mmol) and DMN-AZADO (3.97 mg, 0.024 mmol) at room temperature. The mixture was stirred at 25 C. for 1 h, and a pH 2.3 phosphate buffer was added until the mixture was brought to pH 4 or less. The aqueous layer was then saturated with a common salt, and extracted with dichloromethane. The organic layer was dried over sodium sulfate, and the solvent was evaporated under reduced pressure. The resulting residue was dissolved in a diethyl ether solution, and treated with an excess amount of a diazomethane diethyl ether solution to produce a methyl ester product. After evaporating the solvent under reduced pressure, the product was purified by silica gel column chromatography to give a hydroxy ester compound (51.0 mg, 90%)

According to the analysis of related databases, 144-19-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; TOHOKU UNIVERSITY; Iwabuchi, Yoshiharu; Shibuya, Masatoshi; Doi, Ryusuke; US9114390; (2015); B2;,
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