Month: May 2021

Synthetic Route of 2173-69-5, Adding some certain compound to certain chemical reactions, such as: 2173-69-5, name is 2-Methyl-2-phenyl-1-propanol,molecular formula is C10H14O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2173-69-5.

A solution of 2-METHYL-2-PHENYLPROPAN-1-OL (160mg) (J. Org Chem 1982,47, 2476-2479) in DMF (8ml) under nitrogen was treated with sodium hydride (60% dispersion in mineral oil, 47mg) and the mixture stirred at 20 for 15min. (5R)-3-(6-Bromohexyl)-5-(2, 2- DIMETHYL-4H-1, 3-BENZODIOXIN-6-YL)-1, 3-OXAZOLIDIN-2-ONE (400mg) was then added and the mixture was stirred at 20 for 5h. Phosphate buffer solution (pH 6.5, 15MOI) and water (15ml) were added and the mixture was extracted with EtOAc. The extract was washed with water and dried (NA2SO4). The solvent was evaporated in vacuo and the residue purified by flash chromatography on silica gel. Elution with ETOAC-PETROLEUM ether (1: 4) then (1: 2) gave an oil which was further purified by preparative thin layer chromatography on a silica plate (20 x 20cm). Elution with isopropyl acetate-toluene (2: 3) gave the title compound (100mg). LCMS RT = 3.92 min.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2173-69-5, 2-Methyl-2-phenyl-1-propanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GLAXO GROUP LIMITED; WO2004/37768; (2004); A2;,
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Related Products of 534-03-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 534-03-2, name is 2-Aminopropane-1,3-diol, molecular formula is C3H9NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: A stirred solution of 2-amino-1,3-propanediol (serinol) 4 (1 eq) and triethylamine (TEA) inMeOH (10 mL) was cooled at -20 C (carbon dioxide snow) and added dropwise a solutionof the corresponding acyl chloride (1.1 eq) in THF (5 mL). The reaction mixture was allowed towarm to room temperature and stirred overnight. Then it was poured into brine and extractedwith dichloromethane (3 10 mL). The combined organic phases were washed with brine, driedover MgSO4 and concentrated under reduced pressure. The residue was purified by flash columnchromatography on silica gel using as eluent EtOAc/MeOH (20:1 to 7:1) to provide the correspondingN-acyl serinol derivatives. 4.1.4. N-octanoyl Serinol (5)According to the general procedure serinol 4 (150 mg, 1.64 mmol) was treated with octyl chloride(1.81 mmol, 0.3 mL) and TEA (0.4 mL) to give 267 mg (75%) of 5 as an amorphous white solid.

According to the analysis of related databases, 534-03-2, the application of this compound in the production field has become more and more popular.

Reference:
Article; Jimenez, Aranza; Garcia, Pablo; De La Puente, Sofia; Madrona, Andres; Camarasa, Maria Jose; Perez-Perez, Maria-Jesus; Quintela, Jose-Carlos; Garcia-del Portillo, Francisco; San-Felix, Ana; Molecules; vol. 23; 7; (2018);,
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Application of 23377-40-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 23377-40-4, name is 3-(Hexadecyloxy)propan-1-ol, molecular formula is C19H40O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A suspension of 3-hexadecyloxypropan-1-ol (2.02 g, 6.72 mmol) and DIPEA (4.7 mL, 26.9mmol) in anhydrous methylene chloride (45 mL) was treated dropwise over a 10 minute period with 3-((chloro(diisopropylamino)phosphino)oxy)propanenitrile (3 mL, 13.45 mmol). After 18hours at room temperature, the mixture was quenched with saturated sodium bicarbonate solution (15 mL) and extracted with ethyl acetate (2 x 100 mL). Combined organic phases were concentrated to dryness, and the resulting crude residue purified by chromatography over silica gel (25 mm x 140 mm) using a solvent gradient from 10 to 20% ethyl acetate in hexanes to give hexadecyloxypropyl-(2-cyanoethyl) diisopropylphosphoramidite (2.1 g, 65%) as a white solid. 1H NMR (400 MHz, Chloroform-d) delta 3.89 – 3.54 (m, 6H), 3.49 (t, J= 6.3 Hz, 2H), 3.39 (t, J= 6.7 Hz, 2H), 2.64 (t, J= 6.6 Hz, 2H), 1.87 (p, J = 6.3 Hz, 2H), 1.57 (p, J= 6.3 Hz, 2H), 1.25 (s, 26H), 1.18 (dd, J = 6.8, 3.5 Hz, 12H), 0.87 (t, J= 6.6 Hz, 3H). 31P NMR (162 MHz,Chloroform-d) delta 147.40.

According to the analysis of related databases, 23377-40-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; EMORY UNIVERSITY; PAINTER, George; BLUEMLING, Gregory R.; DE LA ROSA, Abel; LIOTTA, Dennis C.; (124 pag.)WO2017/106710; (2017); A1;,
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Reference of 110-73-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 110-73-6, name is 2-(Ethylamino)ethanol, molecular formula is C4H11NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: To a solution of 2-(chloromethyl)-4-(cyclohexylmethoxy)-1Hbenzo[d]imidazole 7 (0.72 mmol) in DMF (5 mL), K2CO3(0.79 mmol) and appropriate amine 8 or 9 or 10 (0.79 mmol) wereadded. The resulting solution was stirred at 60 C for 3 h. Themixture was cooled, diluted with water, and then extracted withEtOAc. The combined organic extracts were washed with water,brine solution, dried over anhydrous Na2SO4 and then concentratedunder reduced pressure. The crude mixture was subjected to flashsilica gel (230-400 mesh) column chromatography (eluting with0e2% MeOH in dichloromethane) to afford the title compounds 5.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 110-73-6, 2-(Ethylamino)ethanol.

Reference:
Article; Boggu, Pulla Reddy; Kim, Youngsoo; Jung, Sang-Hun; European Journal of Medicinal Chemistry; vol. 181; (2019);,
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Application of 346-06-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 346-06-5, name is (2-(Trifluoromethyl)phenyl)methanol. A new synthetic method of this compound is introduced below.

General procedure: Reactions were performed in a magnetically stirred round bottomed flask fitted with acondenser and placed in a temperature controlled oil bath. 1,2-Diamine (2 mmol)was added to alcohol (3 mmol) and the reaction mixture was allowed to stir at 135°C in an open (air) atmosphere. After disappearance of the diamine (reaction was monitored by TLC)or after the appropriate time, the reaction mixture was cooled to roomtemperature. The crude residue was further purified by column chromatography using silica gel (100-200 mesh) to afford pure products. All the products wereidentified on the basis of NMR and mass spectral data

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,346-06-5, its application will become more common.

Reference:
Article; Marri, Mahender Reddy; Peraka, Swamy; Macharla, Arun Kumar; Mameda, Naresh; Kodumuri, Srujana; Nama, Narender; Tetrahedron Letters; vol. 55; 48; (2014); p. 6520 – 6525;,
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Synthetic Route of 624-95-3 , The common heterocyclic compound, 624-95-3, name is 3,3-Dimethylbutan-1-ol, molecular formula is C6H14O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

EXAMPLE III; Example III illustrates the oxidation of 3, 3-dimethyl-1-butanol to 3, 3-dimethyl-1- butanal using the catalyst system of the current invention: 170 mg ofFe (N03) 3′ 9H20 (0.416mmol), 66mg 2,2′-bipyridyl (0.416mmol), 85mg TEMPO (0.536mmol) and 80mg N-bromosuccinimide (0.45mmol) are dissolved in glacial acetic acid (7 cc) and the solution transferred into a jacketed glass reactor. The reactor is alternately evacuated and purged with oxygen at least five times and the temperature of the catalyst solution is raised to the target value of 45C under constant stirring of 1500RPM. When the temperature reached 45C, 8200 mg of 3, 3-dimethyl-1- butanol (76. 6mmol) are injected through the septum adapter using a gas tight syringe. The recorded oxygen uptake rate is 0. 205mmol 02/min and the GC analysis after 250min reaction time showed 95.2% conversion of the starting alcohol and 96.2% selectivity to the desired 3, 3-dimethyl-l-butanal. The graphical presentation of this reaction is also shown in the same Figure 01, curve 3, NS 10 16.EXAMPLE IV Example TV represents the potential of the catalyst composition to be used at even higher alcohol concentration in direct comparison with Example III. 170 mg of Fe (N03) 3 9H20 (0. 416mmol), 66mg 2,2′-bipyridyl (0. 416mmol), 85mg TEMPO (0. 536mmol) and 80mg N-bromosuccinimide (0. 45mmol) are dissolved in glacial acetic acid (7 cc) and the solution transferred into a jacketed glass reactor. The dissolution and thermostating of the catalyst solution is done as in Example III. When the temperature reached 45C, 9840 mg of3, 3-dimethyl-l-butanol (91. 9mmol) are injected through the septum adapter using a gas tight syringe. The recorded oxygen uptake rate was 0. 184mmol 02/min and the GC analysis after 420min reaction time showed 89.2% conversion of the starting alcohol and 97.4% selectivity to the desired 3, 3-dimethyl-1- butanal. The graphical presentation of this reaction is also shown in the same Figure 01, curve 4, NS1027. EXAMPLE V Example V represents addition protocol in which the catalysts solution and the alcohol are charged in the reactor prior purging the reactor with oxygen and raising the temperature. 170 mg ofFe (N03) 3′ 9H20 (0. 416mmol), 66mg 2, 2′-bipyridyl (0. (d416mmol), 85mg TEMPO (0. 536mmol), 80mg N-bromosuccinimide (0. 45mmol) and 8200 mg of 3, 3-Dimethyl-l-butanol (76. 6mmol) are dissolved in glacial acetic acid (7 cc) and the solution transferred into a jacketed glass reactor. The dissolution and therniostating of the catalyst solution is done as in Example III. When the temperature reached 45C the stirring rate was set to 1500RPM and at this point, monitoring of the oxygen uptake was initiated. The recorded oxygen uptake rate was 0. 220rrunol 02/min and the GC analysis after 230min reaction time showed 96.3% conversion of the starting alcohol and 98.5% selectivity to the desired 3, 3-dimethyl-1-butanal. The graphical presentation of this reaction is also shown in the same Figure 01, curve 5, NS1019.

The synthetic route of 624-95-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; THE NUTRASWEET COMPANY; WO2005/82825; (2005); A1;,
Alcohol – Wikipedia,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 61367-62-2, name is 4-Bromo-3,5-dimethoxybenzyl alcohol. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C9H11BrO3

To a round bottom flask was added (4-bromo-3,5-dimethoxyphenyl)methanol (compound 10, 0.5 g, 2.02 mmol) and NN-dimethylformamide (10 mL). The solution was cooled to 0 °C and sodium hydride (0.100 g of 60percent (w/w) in mineral oil, 2.61 mmol) was added and the reaction was stirred for 1 hour at room temperature. 1-Bromohexane (0.34 mL, 2.43 mmol) was added and the reaction was stirred overnight at room temperature. The reaction was quenched with water and concentrated in vacuo. The residue was taken up in ethyl acetate and washed using water, then brine. The organic layer was dried using sodium sulfate, filtered and concentrated in vacuo. The resulting oil was purified on silica gel using ethyl acetate and hexanes as eluent. Product 2-Bromo-5-((hexyloxy)methyl)-l,3- dimethoxybenzene (16, 0.378 g, 56percent yield) was isolated as a clear oil. LC-MS: tR=2.98 min; m/z+23=353.0, 355.0. 1H NMR (400 MHz, DMSO-d6) delta ppm 6.68 (s, 2 H) 4.43 (s, 2 H) 3.82 (s, 6 H) 3.42 (t, J=6.48 Hz, 2 H) 1.45 – 1.63 (m, 2 H) 1.16 – 1.40 (m, 6 H) 0.85 (t, J=1.00 (0438) Hz, 3 H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 61367-62-2, 4-Bromo-3,5-dimethoxybenzyl alcohol.

Reference:
Patent; SAINT LOUIS UNIVERSITY; WASHINGTON UNIVERSITY; RUMINSKI, Peter, G.; MEYERS, Marvin, L.; HEIER, Richard, F.; RETTIG, Michael, P.; DIPERSIO, John; (139 pag.)WO2018/85552; (2018); A1;,
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Adding a certain compound to certain chemical reactions, such as: 1777-82-8, (2,4-Dichlorophenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of (2,4-Dichlorophenyl)methanol, blongs to alcohols-buliding-blocks compound. Safety of (2,4-Dichlorophenyl)methanol

General procedure: Alcohol (1 mmol) was added to a mixture of MCM-41XANi(II) (0.03 g) and acetic anhydride (0.4 mL), and theresulting mixture was stirred at 50 C in solvent-free condition.After completion of the reaction (mentioned by TLC,ethylacetate: n-hexane, 3:7), dichloromethane (20 mL) wasadded and the catalyst was separated by filtration. Then, themixture was diluted with CH2Cl2.The organic phase washedwith 10% aqueous solution of sodium bicarbonate and driedover Na2SO4.Finally, the organic solvents were evaporatedand the product obtained with high to excellent yield.

The synthetic route of 1777-82-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Nazarzadeh, Somayeh; Ghorbani-Choghamarani, Arash; Tahanpesar, Elham; Journal of the Iranian Chemical Society; vol. 15; 3; (2018); p. 649 – 659;,
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Reference of 4415-82-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 4415-82-1, name is Cyclobutylmethanol. This compound has unique chemical properties. The synthetic route is as follows.

4-Cyclobutylmethoxy-1H-indole-2-carboxylic acid (83) DEAD (2.1 ml, 13.65 mmol) is slowly added to a solution of 4-hydroxy-1 H-indole-2-carboxylic acid ethyl ester 79 (2 g, 9.75 mmol), triphenylphosphine (3.58 g, 13.65 mmol) and cyclobutyl-methanol (1.25 ml, 12.26 mmol) in 20 ml of THF, so that the temperature always remained below 30 OC. Stirring is continued for 2 hours and the solvent is then evaporated. The crude residue is purified by chromatography (cyclohexane : EtOAc/95: 5). Yield : 1. 86 g (70%). MS (ESI) : 274.2 [M+H] +, 1 H-NMR (CDC13) : 5 (ppm) 8.83 (s, 1 H), 7.35 (s, 1H), 7.21 (t, 1H), 6.98 (d, 1H), 6.49 (d, 1H), 4.4 (q, 2H), 4.07 (d, 2H), 2.85 (m, 1H), 2.17 (m, 2H), 1.95 (m, 4H), 1.42 (t, 3H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 4415-82-1, Cyclobutylmethanol.

Reference:
Patent; NOVARTIS AG; NOVARTIS PHARMA GmbH; WO2005/77932; (2005); A2;,
Alcohol – Wikipedia,
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Adding a certain compound to certain chemical reactions, such as: 599-67-7, 1,1-Diphenylethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 599-67-7, blongs to alcohols-buliding-blocks compound. Computed Properties of C14H14O

General procedure: A solvent (5 mL) was placed in a 10 mL round bottom-flask equipped with a magnetic stirrerunder reflux, NXS (1.1 mmol) was then added and, after being dissolved, the substrate (1 mmol) wasadded and the solution was stirred for 4-24 h. The progress of the reaction mixture was monitoredby TLC, whilst the consumption of NXS was tested by KI (0.1 M). Upon completion of the reaction,the crude reaction mixture was cooled down at room temperature, diluted with EtOAc (15 mL),washed with aqueous Na2S2O3 (6 mL), NaHCO3 (6 mL), and water (10 mL), and dried over anhydrousNa2SO4. The solvent was evaporated under reduced pressure and the crude product obtained wasanalyzed by 1H-NMR. The pure final products were obtained after flash chromatography, columnchromatography or preparative thin layer chromatography.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,599-67-7, its application will become more common.

Reference:
Article; Ajvazi, Njomza; Stavber, Stojan; Molecules; vol. 21; 10; (2016);,
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