Month: May 2021

Reference of 355-80-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 355-80-6, name is 2,2,3,3,4,4,5,5-Octafluoro-1-pentanol, molecular formula is C5H4F8O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: A solution of 2-chloro-1,3,2-dioxaphospholane 1 or 2 or 2-chloro-1,3,2-dioxaphosphinane 6 or 7 in 10 mL of hexane was added dropwise with stirring over a period of 2 h to a solution of 0.05 mol of polyfluoroalkanol 3 or 4 and 6.1 g (0.06 mol) of triethylamine in 80 mL of hexane, maintaining the temperature at -10 to -5C. Triethylamine hydrochloride separated from the solution as a white solid. The cooling bath was removed, and the mixture was stirred for 3 h at room temperature and left overnight. The precipitate was filtered off and washed with hexane (3*20 mL). The filtrate was combined with the washings, the solvent was distilled off under reduced pressure, and the residue was distilled in a vacuum.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 355-80-6, 2,2,3,3,4,4,5,5-Octafluoro-1-pentanol.

Reference:
Article; Gusarova; Verkhoturova; Arbuzova; Kazantseva; Albanov; Nalibaeva; Bishimbaeva; Apartsin; Kireeva; Trofimov; Russian Journal of General Chemistry; vol. 88; 4; (2018); p. 705 – 712; Zh. Obshch. Khim.; vol. 88; 4; (2018); p. 623 – 630,8;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.162744-59-4, name is (4-Bromo-2,6-difluorophenyl)methanol, molecular formula is C7H5BrF2O, molecular weight is 223.0148, as common compound, the synthetic route is as follows.Quality Control of (4-Bromo-2,6-difluorophenyl)methanol

Potassium hydroxide (0.377 g, 6.73 mmol) was added to a solution of 6-iodohexan-2-one(80% purity) (2.374 g, 8.40 mmol) in toluene (0.5 mL), followed by the addition of 4-bromo-2,6-difluorobenzylalcohol (1.25 g, 5.60 mmol). The solution mixture was stirred overnight atroom temperature. Water (20 mL) was added to the solution mixture. The mixture was extracted with ethyl acetate (3 x30 mL), and the organic layers were combined, washed with brine, dried over magnesium sulfate, filtered and concentrated under reduced pressure. The crude was purified by column chromatography (dichloromethane/heptane 5:1 to dichloromethane/acetone 4:1) to give 774 mg (43%) of the product. MS (ESIj: m/z 321, 323[M+H]t

At the same time, in my other blogs, there are other synthetic methods of this type of compound,162744-59-4, (4-Bromo-2,6-difluorophenyl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; F2G LIMITED; SIBLEY, Graham Edward Morris; MALMSTROeM, Lars Jonas; LARSSON, Johanna Maria; (212 pag.)WO2017/9651; (2017); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 27489-62-9, name is trans-4-Aminocyclohexanol. A new synthetic method of this compound is introduced below., Computed Properties of C6H13NO

To a round bottom flask with stir bar was added (S)-4-(1-(tert- butoxycarbonylamino)ethyl)-2-chlorobenzoic acid (450 mg, 1.20 mmol), (lr,4r)-4- aminocyclohexanol (415 mg, 3.60 mmol), EDO HCI (460 mg, 2.40 mmol), 1-hydroxy-7-aza- benzotriazole (229 mg, 1.68 mmol) and DMF (6 mL). To this mixture was then added DIEA (629 pL, 3.60 mmol). Reaction mixture was allowed to stir at room temperature for 18 hours. The reaction mixture was diluted with water and extracted with EtOAc. The organic phaseswere combined, washed with twice with water, brine, dried (Na2SO4), filtered and concentrated to a brown crystalline tert-butyl (S)- 1 -(3-chloro-4-((1 r,4S)-4- hydroxycyclohexylcarbamoyl)phenyl)ethylcarbamate (330 mg, 0.83 mmol, 69 % yield). LCMS m/z391.1 (M + H), RtO.71 mm.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 27489-62-9, trans-4-Aminocyclohexanol.

Reference:
Patent; NOVARTIS AG; CHO, Young Shin; LEVELL, Julian Roy; SHAFER, Cynthia; SHULTZ, Michael David; WO2014/147586; (2014); A1;,
Alcohol – Wikipedia,
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Adding a certain compound to certain chemical reactions, such as: 10160-24-4, 7-Bromo-1-heptanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 7-Bromo-1-heptanol, blongs to alcohols-buliding-blocks compound. Recommanded Product: 7-Bromo-1-heptanol

A method for synthesizing cis-7-tetradecenol acetate, which is the main sex pheromone of the elm moth, comprises the following steps:(1) Preparation of (7-bromoheptyl-1 -) – 2-tetrahydropyranyl ether To a 500 ml four-necked flask equipped with an electromagnetic stirrer, a reflux condenser,Pressure dropping funnel in a 250 mL four-necked flask, 3,4-dihydropyran 8 g was added and 0.03 g of 37% hydrochloric acid was added as a catalyst with stirring. After 10 min, a solution of 7-bromo- Alcohol 17 g, control the dropping rate (the reaction is exothermic reaction, 7-bromo-1-heptanol dropping speed is accelerated, the reaction is accelerated, exothermic increase, to be ice bath cooling), keep the reaction temperature of 40 ~ 60 C, add room temperature after reaction 2 h, stop stirring, instead of distillation device, steamed unreacted 3,4-dihydropyran. After the residue was cooled, 85 g of petroleum ether was added, washed with saturated sodium hydrogencarbonate solution and saturated brine, dried over sodium sulfate for 10 to 15 hours, concentrated and evaporated to give (7-bromoheptyl-1- Tetrahydropyranyl ether 23.5 g, purity 99.2%, the yield was 96.7%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,10160-24-4, 7-Bromo-1-heptanol, and friends who are interested can also refer to it.

Reference:
Patent; Shanxi Agricultural University; Yang, Meihong; Chen, Xupeng; Liu, Jinlong; Liu, Hongxia; Zhang, Jintong; Cao, Chuanjian; Jing, Xiaoyuan; Wang, Shifei; Fan, Lihua; (8 pag.)CN105418418; (2016); A;,
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Application of 144-19-4 ,Some common heterocyclic compound, 144-19-4, molecular formula is C8H18O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a 3.8 liter jacketed vessel, 424 grams of 2,2,4-trimethyl-1,3-pentanediol (TMPD Glycol) were charged and heated to a nominal temperature of 150 C. When the TMPD Glycol began to melt, the agitator was switched on to a speed of 400 rpm. In a separate vessel, 1674 grams of 2-ethylhexanoic acid (2-EH) was heated. When the temperature of the 2-EH reached 175 C., it was added to the TMPD Glycol forming a clear solution. The solution was heated until it reached 240 C. The temperature of the vessel contents was controlled by manipulating the temperature of the fluid in the vessel jacket. A sparge of nitrogen was established through a small pipe that discharged 50 cc/min of nitrogen to the base of the vessel under the impeller. Nitrogen purging was discontinued after 1 hours of operation. The pressure of the vessel was atmospheric (760 mmHg). A condenser located in the line between the vessel and the vacuum pump condensed any vapors in the gas and was collected in a receiver vessel where it separated into an aqueous and water layer. The organic layer comprising mainly 2-EH was returned to the vessel while the water layer was removed from the system. During the experiment, samples of the solution were taken at discrete intervals to monitor the progress of the reaction. The results of this experiment are shown in Table 10.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 144-19-4, 2,2,4-Trimethyl-1,3-pentanediol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Eastman Chemical Company; US7674931; (2010); B1;,
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Related Products of 25055-82-7, Adding some certain compound to certain chemical reactions, such as: 25055-82-7, name is 2-(3-Methyl-3H-diazirin-3-yl)ethanol,molecular formula is C4H8N2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 25055-82-7.

4-hydroxy-2-butanone (20, 1.00 g, 11.35 mmol) was pipetted into a dry flask and cooled to 0C under nitrogen atmosphere. 7N methanolic ammonia (11.2 mL, 79 mmol) was added via syringe, and the solution was allowed to stir at 0C for 3 hours. A solution of hydroxylamine-O-sulfonic acid (1.476 g, 13.05 mmol) in methanol (9.7 mL) was added dropwise, then was allowed to stir for an additional 16 hours while slowly warming to room temperature. The reaction was filtered through a sintered glass funnel, then transferred to a reaction vessel and re-cooled to 0C. Triethylamine (1.58 mL,11.35 mmol) was added, then molecular iodine (2.88 g, 11.35 mmol) was added slowly in 10 equal portions until the purple/brown color of iodine persisted in the reaction vessel. The solvent was removed under reduced pressure, and purification of the crude isolate via Kugelrohr distillation (60C, 1-3 torr) delivered the 2,2-diazirinyl intermediate as a clear oil (304 mg, 27% yield). A portion of this intermediate (300 mg, 3.00 mmol) was dissolved in dry pyridine (6 mL) and cooled to 0C in an ice bath. To this solution was added p-toluenesulfonyl chloride (628 mg, 3.30 mmol). The reaction mixture was allowed to stir for 24 hours at 0-4C, then was poured into a mixture of 37%w/v HCl (15 mL) and ice (80 mL). The resulting suspension was extracted 3x with ether, then the pooled organic layers were washed with 1N HCl solution, 1N NaOH solution, water, and brine. The organic extract was dried over MgSO4, vacuum filtered, and concentrated to a clear oil (428 mg, 15% yield over 3 steps) used without further purification. TLC Rf (2:1 hex:EtOAc) = 0.6. 1HNMR (500 MHz, CDCl3) delta 7.82 (d, J = 7.9 Hz, 2H), 7.37 (d, J= 7.9 Hz, 2H), 3.96 (t, J = 6.4 Hz, 2H), 2.46 (s, 3H), 1.68 (t, J= 6.4 Hz, 2H), 1.01 (s, 2H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 25055-82-7, 2-(3-Methyl-3H-diazirin-3-yl)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Yestrepsky, Bryan D.; Kretz, Colin A.; Xu, Yuanxi; Holmes, Autumn; Sun, Hongmin; Ginsburg, David; Larsen, Scott D.; Bioorganic and Medicinal Chemistry Letters; vol. 24; 6; (2014); p. 1538 – 1544;,
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Adding a certain compound to certain chemical reactions, such as: 101597-25-5, 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C17H16O3, blongs to alcohols-buliding-blocks compound. HPLC of Formula: C17H16O3

Example 1 [0193] 1.20 g (2.0 mmol) of a naphthol compound represented by the following formula (22) and 0.80 g (3.0 mmol) of a propargyl alcohol compound represented by the following formula (23) were dissolved in 70 ml of toluene, 0.022 g of p-toluenesulfonic acid was further added to the resulting solution, and the obtained mixture was stirred under reflux by heating for 1 hour. After a reaction, the solvent was removed, and the obtained product was purified on silica gel by chromatography to obtain 1.35 g of a white powder product. The yield was 80 %. [0194] The elemental analysis values of this product were 78.22% of C, 6.72 % of H, 1.55 % of N and 3.75 % of S which were almost equal to the calculated values of C52H52O6 (C: 78.26 %, H: 6.81 %, N: 1.66 %, O: 9.48 %, S: 3.80 %) [0195] When the proton nuclear magnetic resonance spectrum of the product was measured, it showed 18H peaks based on the methyl proton and methylene proton of a tetramethyl-cyclohexane ring at delta of around 1.0 to 3.0 ppm, 20H peaks based on the methyl proton of a methoxy group, the methyl proton of a methylthio group and the ethylene proton of a morpholino group at delta of around 2.3 to 5.0 ppm and 19H peaks based on an aromatic proton and an alkene proton at delta of around 5.6 to 9.0 ppm. Further, when the 13C-nuclear magnetic resonance spectrum was measured, it showed a peak based on the carbon of an aromatic ring at delta of around 110 to 160 ppm, a peak based on the carbon of an alkene at delta of around 80 to 140 ppm and a peak based on the carbon of an alkyl at delta of around 20 to 60 ppm. [0196] It was confirmed from the above results that the isolated product was a compound represented by the following formula (24).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,101597-25-5, 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; Tokuyama Corporation; TAKAHASHI Toshiaki; TAKENAKA Junji; MOMODA Junji; TERANISHI Kazuhiro; SANDO Mitsuyoshi; IZUMI Shinobu; EP2669277; (2013); A1;,
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Synthetic Route of 702-23-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 702-23-8, name is 2-(4-Methoxyphenyl)ethanol. A new synthetic method of this compound is introduced below.

Methoxybenzyl alcohol (64.1g, 420mmol), dichloromethane (530 ml), triethylamine (85.2g, 840mmol) and methanesulfonyl chloride (57.9g, 505mmol) added to the reaction flask and the reaction was stirred at room temperature, the reaction was complete pH was adjusted to neutral, extracted, washed, separated, the organic phase was concentrated under reduced pressure to give a pale yellow oil of 2- (4-methoxy – phenyl) – ethanol methanesulfonate (90.6 g), yield 93.4% .

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,702-23-8, its application will become more common.

Reference:
Patent; Chengdu Hong Pharmaceutical Co., Ltd.; Ke, Xiao; Yan, Jun; (29 pag.)CN103483210; (2016); B;,
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Related Products of 135362-69-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 135362-69-5, name is 3-((4-Methoxybenzyl)oxy)propan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of the mono-PMB-protected diol (20.56 g, 104.8 mmol, 1.0 equiv) inCH2Cl2 (52 mL) at 0 C was added triethylamine (73.0 mL, 524 mmol, 5.0 equiv), DMSO(52 mL), and SO3pyridine (50.0 g, 314 mmol, 3.0 equiv). After stirring for 1.5 h at 0 C,the reaction was quenched with pH 7 phosphate buffer solution (0.5 M, 800 mL). Theaqueous phase was extracted with Et2O (2 × 400 mL), then EtOAc (2 × 400 mL). Theorganics were washed once with brine, dried over Na2SO4, filtered, and concentrated invacuo. Silica gel chromatography (80:20 to 2:1 hexanes/EtOAc) afforded the titlecompound (14.37 g, 71%), with spectroscopic data in agreement with literature values

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 135362-69-5, 3-((4-Methoxybenzyl)oxy)propan-1-ol.

Reference:
Article; Schleicher, Kristin D.; Jamison, Timothy F.; Beilstein Journal of Organic Chemistry; vol. 9; (2013); p. 1533 – 1550;,
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Related Products of 52273-77-5, Adding some certain compound to certain chemical reactions, such as: 52273-77-5, name is 2-(3-Aminophenyl)ethanol,molecular formula is C8H11NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 52273-77-5.

EXAMPLE 2 4-[4-(1-Amino-1-methylethyl)phenyl]-5-chloro-N-[3-(2-hydroxyethyl)phenyl]pyrimidine-2-amine The title compound was prepared from 4-[4-(1-tert-butoxycarbonylamino-1-methylethyl)phenyl]-2,5-dichloropyrimidine (1.50 g, 6.55 mmol) and 2-(3-aminophenyl)ethanol (942 mg, 6.87 mmol) following the method of Example 1. The crude product was purified by chromatography (Silica, 10% methanol in CH2Cl2) to give the title compound as a brown solid (600 mg) m.p. 184-185. deltaH (d6DMSO) 9.77 (1H, s), 8.57 (1H, s), 7.79 (2H, d, J 8.4 Hz), 7.68 (2H, d, J 8.4 Hz), 7.61-7.58 (2H, m), 7.17 (1H, t, J 7.7 Hz), 6.82 (1H, d, J 7.4 Hz), 4.62 (1H, bs), 3.60 (2H, t, J 7.0 Hz), 2.68 (2H, t, J 7.1 Hz), 2.07 (2H, bs), 1.41 (6H, s); MS (ESI) 383 (MH+, 35Cl).

According to the analysis of related databases, 52273-77-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Celltech R & D Limited; US6600037; (2003); B1;,
Alcohol – Wikipedia,
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