Month: May 2021

Reference of 150192-39-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 150192-39-5, name is (2-Bromo-5-methoxyphenyl)methanol, molecular formula is C8H9BrO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step C 2-Bromo-5-methoxybenzaldehyde Pyridinium Chlorochromate (1.2 eq) was added to a solution of 2-bromo-5-methoxybenzyl alcohol (1 eq) and Celite (1.2 eq) in methylene chloride (0.30 M) at RT and the resulting mixture was stirred under nitrogen for 3 h. The mixture was filtered through a plug of silica rinsing with methylene chloride and concentrated in vacuo to give 2-bromo-5-methoxy benzaldehyde as a white solid. EI-MS m/z 232, 234 (M+NH4)+

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 150192-39-5, (2-Bromo-5-methoxyphenyl)methanol.

Reference:
Patent; Amgen Inc.; US6514964; (2003); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 69605-90-9, [1,1′-Biphenyl]-3-ylmethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: alcohols-buliding-blocks, blongs to alcohols-buliding-blocks compound. category: alcohols-buliding-blocks

General procedure: Examples 9a-n were prepared in parallel fashion according to the following method. A stock solution of 8-chloro-3-(cyclopropylmethyl)-7-iodo-[1,2,4]triazolo[4,3-a]pyridine22 (0.9 M in toluene, 1 mL, 0.090 mmol) was added to a 2.0-5.0 mL microwave vial charged with the corresponding commercially available alcohol (0.648 mmol), cesium carbonate (50.0 mg, 0.153 mmol), 1,10-phenanthroline (20.0 mg, 0.111 mmol), and 20.0 mg of copper(I) iodide (20.0 mg, 0.105 mmol). The vials were sealed and heated to 100 C for 17 h. The reaction mixtures were cooled to rt, diluted with 0.5 mL of acetonitrile, and then filtered. The filtrates were concentrated in vacuo at 34 C for 1 h. Each sample was diluted with 0.5 mL of DMF (0.5 mL) and purified using reverse phase preparative LC-MS to afford the title product.

The synthetic route of 69605-90-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Higgins, Mendi A.; Marcin, Lawrence R.; Christopher Zusi; Gentles, Robert; Ding, Min; Pearce, Bradley C.; Easton, Amy; Kostich, Walter A.; Seager, Matthew A.; Bourin, Clotilde; Bristow, Linda J.; Johnson, Kim A.; Miller, Regina; Hogan, John; Whiterock, Valerie; Gulianello, Michael; Ferrante, Meredith; Huang, Yanling; Hendricson, Adam; Alt, Andrew; Macor, John E.; Bronson, Joanne J.; Bioorganic and Medicinal Chemistry; vol. 25; 2; (2017); p. 496 – 513;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 68327-04-8, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 68327-04-8 as follows.

2,6-Difluoro-4-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-indazol-1-yl)-benzonitrile (3 g, 9.51 mmol), (1S,2S)-2-hydroxycyclopentylamine hydrochloride (1.96 g, 14.3 mmol), and diisopropylethylamine (2.46 g, 19 mmol) are combined in DMSO (12 mL) and stirred at 60 C. for 4 h to give 2-fluoro-6-((1S,2S)-2-hydroxy-cyclopentylamino)-4-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-indazol-1-yl)-benzonitrile. The mixture is then diluted with isopropanol (10 mL) and treated three times with 25% aqueous NaOH (1.5 mL) and 30% aqueous hydrogen peroxide (1 mL). The mixture is then partitioned between EtOAc (100 mL) and water (100 mL), and the aqueous layer is washed with additional EtOAc (100 mL). The combined organic layers are concentrated, and the oily residue is purified via chromatography (elution 30 to 100% EtOAc in hexanes). The clean fractions are combined, concentrated and recrystallized from EtOAc/hexanes to give 2-fluoro-6-((1S,2S)-2-hydroxycyclopentylamino)-4-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide (3.53 g, 89%) as a white crystalline solid. LCMS m/z=415 [M+H]-. 1H NMR (400 MHz, d6 DMSO): delta 7.72 (br s, 1H), 7.68 (br s, 1H), 7.38 (d, 1H), 6.72 (d, 1H), 6.61 (dd, 1H), 4.91 (d, 1H), 3.84 (m, 1H), 3.50 (m, 1H), 2.94 (2d, 2H), 2.38 (s, 3H), 2.31 (2 d, 2H), 2.15 (m, 1H), 1.57-1.82 (m, 3H), 1.36 (m, 1H), 1.02 (s, 3H), 1.00 (s, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,68327-04-8, its application will become more common.

Reference:
Patent; Huang, Kenneth He; Ommen, Andy J.; Barta, Thomas E.; Hughes, Philip F.; Veal, James; Ma, Wei; Smith, Emilie D.; Woodward, Angela R.; McCall, W. Stephen; US2008/269193; (2008); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 505-10-2, 3-(Methylthio)propan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 505-10-2, blongs to alcohols-buliding-blocks compound. name: 3-(Methylthio)propan-1-ol

The 3-(methylthio)propan-l-ol 6-a (200 g, 1900 mmol, CAS 505-10-2) was dissolved in CH2C12 (2000 mL). The mixture was cooled to 0C. The w-CPBA 85% in water (970 g, 5700 mmol, CAS 937-14-4) was added portion wise keeping the temperature between 0 and 5C. After addition, the mixture was allowed to warm to 25C and stirred for 15 h. The mixture was filtered through a celite pad. The filtrate was purified by flash column (Eluent: petroleum ether: ethyl acetate = 3 : 1 and then ethyl acetate: methanol = 10: 1) to yield the intermediate 6-b (75 g, 29%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,505-10-2, its application will become more common.

Reference:
Patent; JANSSEN R&D IRELAND; COOYMANS, Ludwig Paul; DEMIN, Samuel Dominique; HU, Lili; JONCKERS, Tim Hugo Maria; RABOISSON, Pierre Jean-Marie Bernard; TAHRI, Abdellah; VENDEVILLE, Sandrine Marie Helene; WO2012/80449; (2012); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 112513-79-8, 6,7-Dihydro-5H-pyrrolo[1,2-a]imidazol-7-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 6,7-Dihydro-5H-pyrrolo[1,2-a]imidazol-7-ol, blongs to alcohols-buliding-blocks compound. Quality Control of 6,7-Dihydro-5H-pyrrolo[1,2-a]imidazol-7-ol

A solution of racemic 6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-7-ol (30 mg), isopropenyl acetate (24-240 mul, 1-30 eq.) and NOV435 (30 mg) in 3.0 mL of solvent (toluene, acetonitrile, tetrahydrofuran or terc-buthyl methyl ester) was stirred gently at 35 C for 7 h in a 4 mL vial. Samples were collected after 3 and 7 h and were directly analyzed by chiral GC for ee of the product and reagent. Conversion (C) was calculated as C = eer/(eer + eep) and enantiomeric ratio (E) was calculated as E = ln[1 – C(1 + eep)]/ln[1 – C(1 – eep)].

The synthetic route of 112513-79-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; De Miranda, Amanda S.; Gomes, Juliana C.; Rodrigues Jr., Manoel T.; Costa, Ingrid C.R.; Almeida, Wanda P.; Lopes, Raquel De O.; Miranda, Leandro S.M.; Coelho, Fernando; De Souza, Rodrigo O.M.A.; Journal of Molecular Catalysis B: Enzymatic; vol. 91; (2013); p. 77 – 80;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 115-20-8, name is Trichloroethanol. A new synthetic method of this compound is introduced below., COA of Formula: C2H3Cl3O

3alpha-Hydroxy-7-oxo-5beta-cholanoic acid (39.0 g, 100 mmol),beta,beta,beta-Trichloroethanol (16.4 g, 110 mmol)Soluble in 150 ml of methylene chlorideStir and cool to 0C.DCC (dicyclohexylcarbodiimide) (24.7 g) was slowly added dropwise.120mmol) dichloromethane solution,After dripping, the reaction was incubated for 6 hours.Filtered, concentrated under reduced pressure, recrystallized from acetonitrile, filtered,Trichloroethyl 3alpha-hydroxy-7-oxo-5beta-cholanoic acid (50.4 g, yield 86.7%) was obtained.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 115-20-8, Trichloroethanol.

Reference:
Patent; Hangzhou Heze Pharmaceutical Technology Co., Ltd.; Ni Sheng; Yang Zhenghe; Chen Jie; Cai Liefeng; Zhou Yinglei; Zhou Liang; Chen Hongxiang; (23 pag.)CN107383139; (2017); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 16545-68-9, Cyclopropanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of Cyclopropanol, blongs to alcohols-buliding-blocks compound. Safety of Cyclopropanol

Step 6: N-methyl-7-cyclopropoxy-6-nitro-1,2,3,4-tetrahydroisoquinoline N-methyl-7-fluoro-6-nitro-1,2,3,4-tetrahydroisoquinoline (150mg, 0.72mmol), sodium tert-butoxide (83mg, 0.86mmol) and N, N-dimethylformamide (5mL) were added to a 25ml reaction flask under nitrogen protection. The reaction was stirred for 10 minutes at 0C, and added with cyclopropanol (54mg, 0.93mmol) in N, N-dimethylformamide (5mL) solution. The reaction was stirred and reacted for 1 hour at 0C. After completion of the reaction, ethyl acetate and water were added to the reaction solution, and the reaction solution was extracted with ethyl acetate twice additionally. The combined organic phase was washed with saturated brine, dried and concentrated. The obtained crude product was separated and purified by column chromatography (silica gel column, eluent: ethyl acetate/petroleum ether, gradient: 0?50%) to obtain the title compound (140mg, 79%). (MS: [M+1] 249.1)

The synthetic route of 16545-68-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Beijing Pearl Biotechnology Limited Liability Company; DONG, Jiaqiang; ZHONG, Boyu; YUAN, Hongbin; SHI, Quan; CHU, Shaosong; ZHANG, Deyi; ZHANG, Ruihao; (219 pag.)EP3150592; (2017); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.6338-55-2, name is 2-(2-(2-Aminoethoxy)ethoxy)ethanol, molecular formula is C6H15NO3, molecular weight is 149.1882, as common compound, the synthetic route is as follows.HPLC of Formula: C6H15NO3

A solutionof 2-[2-(2-aminoethoxy)ethoxy]ethanol (0.41 g, 2.75 mmol, 1.1 eq.) and Et3N (660 L, 4.75mmol, 1.9 eq.) in methanol (15 mL) was stirred at 30C for 1 h. NBD-Cl (0.5 g, 2.50 mmol, 1eq.) was added and the reaction was stirred in the dark for 16 h at 30C. Insoluble material wasremoved by filtration, and the filtrate was dried. The resulting solid was dissolved in H2O (5mL) and purified on a sephadex LH-20 column, eluting with H2O to give the product as anorange solid (0.33 g, 1.05 mmol, 42% yield).LRMS (ESI-): m/z calculated 311.10 ([M-H]-), found 311.18 ([M-H]-), (ESI+): m/z calculated335.27 ([M+Na]+), found 335.09 ([M+Na]+); HRMS (ESI+): m/z calculated 335.09621([M+Na]+) for C12H16N4O6Na, found 335.09650 ([M+Na]+).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,6338-55-2, 2-(2-(2-Aminoethoxy)ethoxy)ethanol, and friends who are interested can also refer to it.

Reference:
Article; Glenister, Alexandra; Simone, Michela I.; Hambley, Trevor W.; PLoS ONE; vol. 14; 7; (2019);,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 7397-62-8, Adding some certain compound to certain chemical reactions, such as: 7397-62-8, name is Butyl 2-hydroxyacetate,molecular formula is C6H12O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7397-62-8.

175.16 g (99%) of o-cresol and 214.10 g (99%) of n-butyl glycolate,And the catalyst Mo2P5-MCM-48 (Mo2P5 and MCM-48 mass ratio of 25:100) 1.32g was put into the reaction rectification apparatus, mixed and stirred, and the temperature was raised to 120 C, and the reaction was carried out for 3 hours.When the top of the column is substantially anhydrous, the reaction is completed, the temperature is lowered to room temperature, the catalyst is filtered off, and the filtrate is distilled to recover 64.85 g of o-cresol.a mixture of 48.94 g of n-butyl glycolate, 118.54 g,The product obtained n-butyl tolyloxyacetate 223.82g, purity 98.9%,The yield was 99.2% based on phenol.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 7397-62-8, Butyl 2-hydroxyacetate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Shandong Runbo Biological Technology Co., Ltd.; Sun Guoqing; Hou Yongsheng; Chi Zhilong; Zhang Liguo; Hu Yishan; (13 pag.)CN108947839; (2018); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 2568-33-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 2568-33-4, name is 3-Methylbutane-1,3-diol. This compound has unique chemical properties. The synthetic route is as follows.

Step 1. Preparation of 3-hydroxy-3-methylbutyl 4-methylbenzenesulfonate To a solution of 3-methylbutane-l,3-diol (1.00 g, 9.60 mmol) in pyridine (10 mL) at 0 C was added -toluenesulfonyl chloride (2.014 g, 10.56 mmol). The reaction mixture was stirred for 16 h while allowing the reaction mixture to slowly warm up to room temperature by dissipation of the ice-water bath. The mixture was transferred to a separatory funnel containing ethyl acetate (100 mL). The organic layer was washed with 1 N HQ (3 x 50 mL). The organic layer was then washed with saturated aHC03 solution (50 mL), brine (50 mL), dried over MgS04, filtered, and concentrated. The product was purified by column chromatography on silica gel (30%? 50% ethyl acetate in hexanes; 220 g column) to afford 3-hydroxy-3-methylbutyl 4-methylbenzenesulfonate (2.03 g, 7.86 mmol, 82% yield) as a colorless oil: XH NMR (400MHz, CHLOROFORM- d) delta 7.85 – 7.78 (m, 2H), 7.37 (dd, J=8.5, 0.8 Hz, 2H), 4.23 (t, J=6.9 Hz, 2H), 2.47 (s, 3H), 1.88 (t, J=6.9 Hz, 2H), 1.24 (s, 6H); LC/MS: The product did not ionize, tR = 1.78 min (method 2-1).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 2568-33-4, 3-Methylbutane-1,3-diol.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; SIT, Sing-Yuen; CHEN, Yan; CHEN, Jie; SWIDORSKI, Jacob; VENABLES, Brian Lee; SIN, Ny; MEANWELL, Nicholas A.; REGUEIRO-REN, Alicia; HARTZ, Richard A.; XU, Li; LIU, Zheng; WO2015/157483; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts