Month: May 2021

Adding a certain compound to certain chemical reactions, such as: 17849-38-6, 2-Chlorobenzyl alcohol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 2-Chlorobenzyl alcohol, blongs to alcohols-buliding-blocks compound. Recommanded Product: 2-Chlorobenzyl alcohol

a) 100 ml of HBr (48%) were heated to 90 and treated portionwise with 1.43 g (0.01 mol) of 2-chlorobenzyl alcohol. The mixture was stirred for 1/4 hr. and then cooled to room temperature. The mixture was extracted with ethyl acetate and the organic phase was washed with water and saturated sodium chloride solution and dried over sodium sulfate. 1.75g (85%) of 2-chlorobenzyl bromide were obtained as a slightly turbid, colorless oil; b.p. 130/30 mmHg.

The synthetic route of 17849-38-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Hoffmann-La Roche Inc.; US5753679; (1998); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 4254-29-9, 2,3-Dihydro-1H-inden-2-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 4254-29-9, blongs to alcohols-buliding-blocks compound. Recommanded Product: 4254-29-9

2-hydroxy indan (100 g) was dissolved in 1,2-dichloroethane (400 ml) and added to thionyl chloride (125 g) slowly over a period of an hour. Temperature was maintained at less than 10 C. Thereafter, the reaction mass was slowly heated and refluxed till the completion of the reaction. The reaction was monitored by TLC. The reaction mass was cooled to room temperature and poured in to ice water, stirred for 1 hour and organic layer was separated. The aqueous layer was extracted with dichloroethane. Organic layers were combined and washed with water, sodium bicarbonate solution and dried over anhydrous sodium sulphate. Solvent was distilled out completely and the crude product was distilled under vacuum to obtain 2-chloroindan as a colorless liquid (118 g).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,4254-29-9, 2,3-Dihydro-1H-inden-2-ol, and friends who are interested can also refer to it.

Reference:
Patent; REDDY, G. Pratap; SUNKU, Venkataiah; BABU, Sunkaraneni Suresh; (14 pag.)US2018/215714; (2018); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 445-26-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 445-26-1, name is 1-(2-Fluorophenyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

Example 126 1-(2-Fluorophenyl)ethyl N-{2-chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl}carbamate 2-Chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]aniline (83 mg) was added to toluene/triethylamine = 10/1 (8 ml), and the mixture was heated under reflux to prepare a solution. A solution of triphosgene (134 mg)in methylene chloride was then added to the solution, and the mixture was heated under reflux for 15 min. Subsequently, 2-fluoro-alpha-methylbenzyl alcohol (55 mg) was added thereto, and the mixture was further stirred with heating under reflux for 2 hr. After the completion of the reaction, the reaction solution was allowed to cool to room temperature before distilled water was added thereto. The mixture was subjected to separatory extraction with chloroform, followed by washing with a 1 N aqueous hydrochloric acid solution and saturated brine. The washed solution was dried over sodium sulfate and was concentrated. The residue was purified on a column using chloroform/methanol to give the title compound (60 mg, yield 45%). 1H-NMR (CDCl3, 400 MHz): 8.80 (1H, s), 8.37 (1H, d, J = 9.2 Hz), 8.15 (1H, s), 7.58 (1H, s), 7.43 – 7.52 (1H, m), 7.32 (1H, d, J = 2.7 Hz), 7.28 – 7.35 (1H, m), 7.15 – 7.20 (2H, m), 7.06 – 7.11 (1H, m), 6.19 (1H, q, J = 6.6 Hz), 4.19 (3H, s), 4.12 (3H, s), 1.66 (3H, d, J = 6.6 Hz) Mass spectrometry value (ESI-MS, m/z): 499 (M++1)

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 445-26-1, 1-(2-Fluorophenyl)ethanol.

Reference:
Patent; KIRIN BEER KABUSHIKI KAISHA; EP1243582; (2002); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 29683-23-6, Tetrahydro-2H-thiopyran-4-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: Tetrahydro-2H-thiopyran-4-ol, blongs to alcohols-buliding-blocks compound. name: Tetrahydro-2H-thiopyran-4-ol

Tetrahydro-2H-thiopyran-4-ol 23a (350 mg, 2.97 mmol, prepared by a method disclosed in EP Patent Application Publication EP1466898 A1) was placed in a reaction flask, followed by addition of triethylamine (606 mg, 5.94 mmol), 4-dimethylaminopyridine (36 mg, 0.30 mmol), 20 mL of dichloromethane, and p-toluenesulfonyl chloride (848 mg, 4.45 mmol). After reacting for 12 hours, the reaction solution was mixed with 30 mL of water, and left to stand and separate. The aqueous phase was then extracted with dichloromethane (10 mL*2). The organic phases were combined, washed with saturated sodium chloride solution (30 mL), dried over anhydrous sodium sulfate, and filtered. The filtrate was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography with elution system B to obtain the title compound tetrahydro-2H-thiopyran-4-yl-4-methylbenzenesulfonate 23b (556 mg, yield 68.9%) as a white solid.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,29683-23-6, Tetrahydro-2H-thiopyran-4-ol, and friends who are interested can also refer to it.

Reference:
Patent; Shanghai Hengrui Pharmaceutical Co., Ltd.; Jiangsu Hengrui Medicine Co., Ltd.; Lu, Hejun; Sun, Piaoyang; Fei, Hongbo; Jiang, Hongjian; Wang, Haowei; Dong, Qing; US2015/225381; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 13674-16-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 13674-16-3, name is Methyl 2-hydroxy-3-phenylpropanoate. This compound has unique chemical properties. The synthetic route is as follows.

[0177] Example 18: Synthesis of 2-(4 -AMINO-BIPHENYL-4-YLOXY)-3-PHENYL-PROPIONIC acid methyl ester.; [0178] Step 1: 2- (4 -NITRO-BIPHENYL-4-YLOXY)-3-PHENYL-PROPIONIC acid methyl ester. A mixture OF 4 -HYDROXY-4-NITRO-BIPHENYL (4.12 g, 19.1 mmol), prepared in step 2 of Example 16, 2-hydroxy-3-phenyl-propionic acid methyl ester (3.35 g, 18. 5 mmol) and triphenylphosphine (4.12 g, 19.1 MMOL.) in diethyl ether was cooled under nitrogen to 0C. Diisopropyl azodicarboxylate (6.09 mL, 30.96 mmol) was then added and the reaction allowed to come to room temperature and then stirred overnight at room temperature. The reaction was concentrated under reduced pressure. Purification of the residue on silica gel using 15% ethyl acetate hexanes as the eluent gave 2- (4 -NITRO-BIPHENYL-4-YLOXY)-3-PHENYL-PROPIONIC acid methyl ester.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 13674-16-3, Methyl 2-hydroxy-3-phenylpropanoate.

Reference:
Patent; WYETH; WO2005/30702; (2005); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 23147-58-2, Adding some certain compound to certain chemical reactions, such as: 23147-58-2, name is Glycerol aldehyde dimer,molecular formula is C4H8O4, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 23147-58-2.

A solution of 5-methoxy-l-indanone (500 mg, 3.08 mmol) in methanol (10 mL) was treated with 10% palladium on carbon (53 mg) followed by glycoaldehyde dimer (370 mg, 3.08 mmol) and 0.5M sodium methoxide in methanol (1.3 mL, 0.65 mmol). The mixture was placed under a hydrogen atmosphere (balloon) and stirred vigorously at room temperature for 65 hours. After purging with nitrogen, the mixture was filtered through a 0.45 mum Acrodisc and the disk was rinsed with methanol (2 mL). The filtrate was diluted with EtOAc (25 mL), washed with 0. IN HCl (15 mL) and brine (15 mL), dried over MgSOphi filtered, and evaporated under vacuum to a solid. LC-MS of this material showed a mixture of starting material (major) and product. The mixture was purified by chromatography on a Biotage Flash 12M KP-SiI column (12 mm x 15 cm). The column was eluted with 3:2 EtOAc-hexanes, collecting 6 mL fractions every 30 sec. EPO Fractions 20-36 were concentrated under vacuum and flashed with benzene to afford 2-(2-hydroxyethyl)- 5-methoxy-l-indanone as an oil. 1H NMR (CDCl3, 500 MHz) delta 1.80 and 2.05 (two m, CH2CH2OH), 2.79 and 3.35 (two dd, 3-CH2), 2.83 (m, H-2), 3.77-3.90 (m, CH2CH2OH), 3.87 (s, OCHj), 6.86 (d, H-4), 6.89 (dd, H-6), and 7.67 (d, H- 7).

According to the analysis of related databases, 23147-58-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MERCK & CO., INC.; WO2006/50399; (2006); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 24034-73-9, name is (2E,6E,10E)-3,7,11,15-Tetramethylhexadeca-2,6,10,14-tetraen-1-ol. A new synthetic method of this compound is introduced below., Safety of (2E,6E,10E)-3,7,11,15-Tetramethylhexadeca-2,6,10,14-tetraen-1-ol

To a solution of polymer bound triphenylphosphine (68 mg, 0.20 mmol, 3.0 mmol/g substitution) and carbon tetrabromide (68 mg, 0.20 mmol) in dry CH2Cl2 was added geranylgeraniol (56 muL, 0.17 mmol), and the reaction was stirred for 2 h. The polymeric reagent was removed by filtration and the solvents removed in vacuo. This crude product is stable overnight in the freezer, but was generally used directly in the Zn2+ catalyzed geranylgeranylation reactions after purification on a C18 SepPak column. The SepPak purification removes an unknown impurity that greatly increases the amount of undesirable disulfide peptide dimer formed instead of the desired geranylgeranylation of cysteine.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 24034-73-9, (2E,6E,10E)-3,7,11,15-Tetramethylhexadeca-2,6,10,14-tetraen-1-ol.

Reference:
Article; Ochocki, Joshua D.; Mullen, Daniel G.; Wattenberg, Elizabeth V.; Distefano, Mark D.; Bioorganic and Medicinal Chemistry Letters; vol. 21; 17; (2011); p. 4998 – 5001;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 56239-26-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 56239-26-0, name is cis-4-Aminocyclohexanol hydrochloride, molecular formula is C6H14ClNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To tert-butyl 3-(5-chloro-2-fluoropyridin-4-yl)phenyl((tetrahydro-2H-pyran-4- yl)methyl)carbamate (440 mg, 1.045 mmol) was added DMSO (4 ml), TEA (0.729 ml, 5.23 mmol), and (ls,4s)-4-aminocyclohexanol hydrochloride (476 mg, 3.14 mmol) . The reaction was stirred at 95-100 °C for 40 hr. The reaction was followed by LCMS. The reaction was let cool, added 250 ml of ethyl acetate, washed with saturated sodium bicarbonate, water (2x), filtered and concentrated to constant mass. The crude was purified by silica gel chromatography using 12g column eluting with 30-85percent ethyl acetate with heptane. The desired fractions were concentrated to constant mass, giving 363 mg of the titled compound as free base used without further purification. LCMS (m/z): 516.2 (MH+), rt = 0.80 min.

According to the analysis of related databases, 56239-26-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NOVARTIS AG; ANTONIOS-MCCREA, William R.; BARSANTI, Paul A.; HU, Cheng; JIN, Xianming; MARTIN, Eric J.; PAN, Yue; PFISTER, Keith B.; SENDZIK, Martin; SUTTON, James; WAN, Lifeng; WO2012/66065; (2012); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 1124-63-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1124-63-6, name is 3-Cyclohexylpropan-1-ol. A new synthetic method of this compound is introduced below.

(9-1) Synthesis of 3-bromopropylcyclohexane (compound 9-1) [Show Image] 3-Cyclohexyl-1-propanol (5.00 g) was dissolved in methylene chloride (50 ml), triphenylphosphine (10.2 g) and N-bromosuccinimide (6.90 g) were added under ice-cooling, and the mixture was stirred under ice-cooling for 1 hr, and further at room temperature for 1 hr. The reaction mixture was washed with water and saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure. Diethyl ether (100 ml) was added, and the precipitated triphenylphosphine oxide was filtered off. The concentrate of the filtrate was purified by silica gel column chromatography (hexane alone) to give the object product (7.17 g) as a colorless oil. 1H-NMR(CDCl3) delta (ppm): 0.81-0.96(2H, m), 1.10-1.45(6H, m), 1.60-1.78(5H, m), 1.82-1.92(2H, quint, J=7.0Hz), 3.39(2H, t, J=7.0Hz).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1124-63-6, 3-Cyclohexylpropan-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; Mitsubishi Tanabe Pharma Corporation; EP2168944; (2010); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 928-51-8, Adding some certain compound to certain chemical reactions, such as: 928-51-8, name is 4-Chlorobutan-1-ol,molecular formula is C4H9ClO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 928-51-8.

Example 6 Synthesis of 4-(nitrooxy)butyl 4-phenyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa- 1 ,4-dienyl)butanoate (Compound 6) Step 1 : Synthesis of 4-chlorobutyl 4-nitrobenzoate To a solution of 4-Chlorobutanol (1.09 g; 10.04 mmol) and TEA (1.7 ml; 12.05 mmol) in CH2C12 (25 ml) cooled at 0C, 4-Nitrobenzoyl chloride (2.23 g; 12.05 mmol) was added portionwise. The mixture was stirred 2 hours at room temperature then was washed with NaH2P04 (25 ml), H20 and brine. The residue was purified by flash chromatography (Biotage SPl instrument, SNAP cartridge silica 100 g, n-Hexane/EtOAc 9: 1, 10 CV) affording the title compound (2.48 g; Yield: 96%) 1H NMR (300 MHz, CDC13) delta 8.38-8.25 (m, 2H), 8.25-8.14 (m, 2H), 4.55-4.33 (m, 2H), 3.73-3.53 (m, 2H), 2.13-1.85 (m, 4H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 928-51-8, 4-Chlorobutan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NICOX SCIENCE IRELAND; ALMIRANTE, Nicoletta; STORONI, Laura; RONSIN, Gael; BASTIA, Elena; WO2014/170264; (2014); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts