Month: May 2021

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 15753-50-1, name is cis-Cyclohexane-1,2-diyldimethanol, the common compound, a new synthetic route is introduced below. HPLC of Formula: C8H16O2

4) Preparation of ethyl 1-((2-tosyloxymethyl) cyclohexyl) carboxylate used at the start of Example 16. Formation of the Ester 2.23 ml of ethyl diazoacetate in solution in 16 ml of dichloromethane is added over 1 hour at ambient temperature to 3.06 g of cis 1,2-cyclohexane dimethanol in 100 ml of dichloromethane in the presence of a few drops of ethyl etherate borotrifluoride. The reaction medium is maintained under agitation for 16 hours at ambient temperature, followed by washing with water and drying, the solvent is evaporated off under reduced pressure, the residue is chromatographed on silica (eluant: AcOEt/cyclohexane 20-80) and 1.98 g of expected product is obtained.

The synthetic route of 15753-50-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Hoechst Marion Roussel; US6143774; (2000); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 5333-42-6 , The common heterocyclic compound, 5333-42-6, name is 2-octyldodecan-1-ol, molecular formula is C20H42O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

2-Octyl-l-dodecanol (20 ml, 56.14 mmol) and anhydrous triethylamine (16 ml, 112.28 mmol) were dissolved in dry dichloromethane (60 ml). The solution was cooled to 0 0C and methanesulfonyl chloride (5.2 ml, 67.36 mmol) in dry dichloromethane (40 ml) added dropwise. After completion of the addition, the mixture was stirred at 0 0C for 3 hours and then refrigerated (2-8 C) overnight. The reaction mixture was poured on ice (500 grams), allowed to warm to room temperature, and extracted with ether (3 x 150 ml). . The organic phase was washed consecutively with water (150 ml), 2 % H2SO4 (150 ml), water (150 ml), saturated sodium bicarbonate (150 ml) and again with water (150 ml). The organic phase was dried over 176 anhydrous Na2SO4 and the solvent was removed under reduced pressure, yielding 22.8 grams of methanesulfonic acid 2-octyl-dodecyl ester as a yellow oil.

The synthetic route of 5333-42-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; VASCULAR BIOGENICS LTD.; KOVALEVSKI-ISHAI, Eti; ZINIUK, Zeev; HALPERIN, Gideon; MENDEL, Itzhak; FEIGE, Erez; YACOV, Niva; BREITBART, Eyal; WO2010/52718; (2010); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 495-76-1, name is Benzo[d][1,3]dioxol-5-ylmethanol. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of Benzo[d][1,3]dioxol-5-ylmethanol

General procedure: Oxidative coupling of alcohols and amines was performed in aWP-TEC-1020HC parallel reactor provided by WATTCASTM (WATTECSLAB EQUIPMENT CO., LTD.). In a typical protocol, 0.5 mmolbenzyl alcohol, 0.75 mmol aniline, 5 mL toluene and 40 mg catalystwere added successively. And then the reaction mixture was stirred (900 rpm) at 60 C under air (1 atm) for 8 h. The tube wasimmediately cooled in ice water and the reaction mixture wasanalysed using a Thermo Scientific TRACE 1310 gas chromatograph(GC) equipped with a flame ionization detector (FID) and a TR-5column (30 m 0.32 mm 0.25 lm). The quantification was carriedout using the external standard method. A series of toluenesolutions in different concentrations of benzyl alcohol, benzaldehydeor benzylideneaniline were used as external standard, respectively.Each reaction was at least repeated twice to guarantee areproducible result. The conversion of benzyl alcohol, the selectivityto alkylamines and the yield of imine were calculated, on thebasis of a carbon balance. For the reusability test, the catalystwas separated by centrifugation (8000 rpm for 10 min), washedthree times in turn with ethanol (100 mL) and water (100 mL),dried at 50 C for 24 h under vacuum, and was used for the nextrun.

With the rapid development of chemical substances, we look forward to future research findings about 495-76-1.

Reference:
Article; Wu, Shipeng; Sun, Weixiao; Chen, Junjie; Zhao, Jinghan; Cao, Qiue; Fang, Wenhao; Zhao; Journal of Catalysis; vol. 377; (2019); p. 110 – 121;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 4845-50-5 , The common heterocyclic compound, 4845-50-5, name is 1,4-Dioxane-2,3-diol, molecular formula is C4H8O4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

5-bromo-3-chloro-1 ,2-diaminobenzene (4.6 g; 20 mmol; 1 .0 eq.) was dissolved in EtOH (200 ml_) and then 2,3-dihydroxy-1 ,4-dioxane (2.5 g, 20 mmol; 1 .0 eq.) was added. The mixture was stirred for 4 h at RT and a second portion of 2,3-dihydroxy-1 ,4-dioxane (1 .3 g; 10 mmol; 0.5 eq.) was added. After stirring for 24 h at rt, RM was concentrated in a rotary evaporator and the residue was purified by FCC to provide 7-bromo-5- chloroquinoxaline (Intermediate 3) as a beige solid (4.7 g; yield 92 %; 98 % by UPLC).

The synthetic route of 4845-50-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK PATENT GMBH; BUCHSTALLER, Hans-Peter; (101 pag.)WO2018/87021; (2018); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 52273-77-5 ,Some common heterocyclic compound, 52273-77-5, molecular formula is C8H11NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

2- (3-aminophenyl) ethanol (3. 01G, 21. 9mmol), acetone (53ml) and conc. HCl (9ml) was mixed and cooled to 0C. Sodium nitrite (1.86g, 21. 9MMOL) dissolved in 4ML water was added. The temperature was kept under 0C. After 1H methyl acrylate (18. 9g, 219. 4MMOL) was added and then Cu (I) I (0.42g, 2. 19MMOL) in portions. The mixture was stirred at room temperature over night. The acetone was evaporated and water was added. The water phase was extracted three times with ethyl acetate. The organic phases were pooled and washed (water, brine), dried (MGS04) and evaporated. The crude product was purified by flash chromatography using a 60: 40 mixture of ethyl acetate/toluene as eluent to yield 2.95g of the desired product (yield 55%). 1HNMR (400MHZ, CDC13) : 2. 85 (t, 2H), 3.16 (dd, 1H), 3.35 (dd, 1H), 3.74 (s, 3H), 3.85 (t, 2H), 4.45 (t, 1H), 7.05-7. 28 (M, 4H)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 52273-77-5, 2-(3-Aminophenyl)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2004/113282; (2004); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 14631-46-0 ,Some common heterocyclic compound, 14631-46-0, molecular formula is C9H11NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

The intermediate 8-hydroxy-5,6,7,8-tetrahydroquinoline was prepared according to the procedure described in Bridger et. al. PCT International application PCT/CA00/00321. For the purposes of illustration, the synthesis of (R)-(-)-8-amino-5,6,7,8-tetrahydroquinoline is described.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,14631-46-0, its application will become more common.

Reference:
Patent; McEachern, Ernest J.; Bridger, Gary J.; Skupinska, Krystyna A.; Skerlj, Renato T.; US2003/114679; (2003); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 2009-83-8, Adding some certain compound to certain chemical reactions, such as: 2009-83-8, name is 6-Chlorohexan-1-ol,molecular formula is C6H13ClO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2009-83-8.

(1), in order to P-nitro phenol, 6- chlorine oneself alcohol and sodium hydroxide is used as a raw material, molar ratio of 1 : 1.2: 1.3, water as the solvent, 85 C reaction 6 hours to obtain P-nitrophenyl oxygen hexanol, after filtering first, solid for the removal of residual nitro phenol, filtered, the solid is dried in a vacuum oven, to obtain the product.Repeat embodiment 1 is the same as the steps in the operation of (2) (3) (4) (5) (6) (7) (8).

According to the analysis of related databases, 2009-83-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Changzhou University; Xue, Xiaoqiang; Jiang, Bibiao; Huang, Wenyan; Yang, Hongjun; (9 pag.)CN105732417; (2016); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 55414-72-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 55414-72-7, name is (2-Amino-5-methoxyphenyl)methanol, molecular formula is C8H11NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A solution of compound 8 (240 mg, 1.22 mmol) and EDC·HCl (277 mg, 1.44 mmol) in DMF (2 mL) was stirred at room temperature for 5 min, then cooled to 0 C. To this solution was added successively 1-hydroxybenzotriazole (195 mg, 1.44 mmol), a solution of compound 4 (207 mg, 1.35 mmol) in DMF (2 mL), and triethylamine (0.25 mL, 1.80 mmol). The mixture was warmed to room temperature and stirred under N2 atmosphere for 6 h. The solvent was removed under reduced pressure and the crude product was partitioned between aqueous HCl (10 mL, 1 N) and ethyl acetate (20 mL). The aqueous layer was extracted with ethyl acetate (4 * 20 mL). The organic layers were combined and washed with water (10 * 20 mL), then dried with MgSO4 and concentrated onto silica under reduced pressure. The residue was subjected to flash chromatography eluting with 1:9?3:7 ethyl acetate/dichloromethane, to afford the title compound as a pale yellow solid (238 mg, 59%); mp 168-170 C; IR (neat) numax (cm-1): 3375, 3257, 3067, 3021, 2946, 2840, 2656, 2321, 2085, 2008, 1926, 1790, 1647, 1578, 1538, 1505; 1H NMR (400 MHz, CD3CN) delta 8.64 (s, 1H, NH), 8.14 (d, J = 9.1 Hz, ArH3), 7.66 (d, J = 8.7 Hz, ArH6′), 7.20 (d, J = 2.8 Hz, ArH6), 7.15 (dd, J = 9.1, 2.8 Hz, ArH4), 6.98 (d, J = 3.0 Hz, ArH3′), 6.92 (dd, J = 8.7, 3.0 Hz, ArH5′), 4.63 (s, 2H, CH2), 3.94 (s, 3H, OCH3), 3.77 (s, 3H, OCH3), 3.45 (s, 1H, OH); 13C{1H} NMR (101 MHz, CD3CN) delta 165.8 (C=O), 164.9 (C5), 158.6 (C4′), 140.2 (C1), 137.1 (C1′), 136.6 (C2), 129.1 (C2′), 128.2 (C3), 126.7 (C6′), 115.9 (C4), 115.1 (C6), 114.4 (C3′), 113.7 (C5′), 62.5 (CH2), 57.2 (OCH3), 56.1 (OCH3); HRMS (ESI,+ve) C16H16N2O6Na+ [MNa+] requires m/z 355.0901, found 355.0894.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 55414-72-7, (2-Amino-5-methoxyphenyl)methanol.

Reference:
Article; Lizarme, Yuvixza; Wangsahardja, Jonatan; Marcolin, Gabriella M.; Morris, Jonathan C.; Jones, Nicole M.; Hunter, Luke; Bioorganic and Medicinal Chemistry; vol. 24; 7; (2016); p. 1480 – 1487;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 39067-45-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 39067-45-3, name is 3-(Diethylamino)-2,2-dimethylpropan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE III 3-Diethylamino-2,2-dimethylpropyl 3,4-dimethoxyphenylcinnamate hydrochloride 3,4-Dimethoxycinnamic acid (31.4 g, 0.15 mole) was added with rapid stirring to thionyl chloride (52.5 ml) and refluxed for 4 hours. The mixture was stripped of excess thionyl chloride under reduced pressure, benzene (100 ml) was added, and the mixture was again stripped of solvent. The residue was treated with a solution of 3-diethylamino-2,2-dimethylpropanol (24.2 g, 0.15 mole) in benzene (500 ml), refluxed for 3 hours, cooled, diluted with petroleum ether (500 ml), and stored overnight at room temperature. The benzene-petroleum ether solution was decanted, the residue dissolved in H2 O (800 ml), and the solution adjusted to pH 8 with saturated aqueous K2 CO3 (60 ml). The product was extracted from the aqueous phase with benzene (800 ml) in portions and the extract dried overnight over MgSO4 and Darco. The solution was filtered and the filtrate adjusted to pH 3 with a solution of dry HCl in ether (cooled in ice bath). Petroleum ether (500 ml) was added and the product oiled out of solution. The benzene-petroleum ether solution was decanted, chloroform (5-0 ml) was added and the mixture was stripped to dryness under reduced pressure. This procedure was repeated three times and then the residue was washed with anhydrous ether (scratching induced crystallization). The product was collected by filtration, yield: 34 g (59%). A sample was recrystallized from ethyl acetate, m.p. 135-138. Anal. Calc’d for C20 H31 NO4.HCl: C, 62.24; H, 8.36; N, 3.63. Found: C, 62.43; H, 8.37; N, 3.62.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 39067-45-3, 3-(Diethylamino)-2,2-dimethylpropan-1-ol.

Reference:
Patent; Morton-Norwich Products, Inc.; US3946042; (1976); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 3391-10-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 3391-10-4, name is 1-(4-Chlorophenyl)ethanol. A new synthetic method of this compound is introduced below.

General procedure: In a test tube, 1,3-dicarbonyl compound (1.5 mmol), alcohol or alkene (1.0 mmol) and catalyst (0.013 mmol) were mixed and stirred at 100 C for 5 h under solvent-free conditions. At the end of the reaction, Et2O (10 ml) was added and the catalyst was filtered. The pure product was isolated by chromatography on a silica gel plate (petroleum ether/ethylacatate = 9/1).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3391-10-4, its application will become more common.

Reference:
Article; Barati, Behjat; Moghadam, Majid; Rahmati, Abbas; Mirkhani, Valiollah; Tangestaninejad, Shahram; Mohammadpoor-Baltork, Iraj; Catalysis Communications; vol. 29; (2012); p. 122 – 126;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts