Month: May 2021

Related Products of 56456-49-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.56456-49-6, name is 4-Chloro-2-fluorobenzyl alcohol, molecular formula is C7H6ClFO, molecular weight is 160.5733, as common compound, the synthetic route is as follows.

To a solution of (4-chloro-2-fluorophenyl)methanol (222 mg) in MeCN (20 mL) was added MnC>2 (480 mg). The mixture was stirred for 24h. The mixture was filtered over celite, the org. layer was dried over MgS04 and evaporated in vacuo. The crude aldehyde was used without purification in the next step. LC-MS (A): tR = 0.76 min; [M+H]+: not visible.

Statistics shows that 56456-49-6 is playing an increasingly important role. we look forward to future research findings about 4-Chloro-2-fluorobenzyl alcohol.

Reference:
Patent; ACTELION PHARMACEUTICALS LTD; BUR, Daniel; GRISOSTOMI, Corinna; NAYLER, Oliver; REMEN, Lubos; VERCAUTEREN, Magali; WELFORD, Richard; WO2015/75023; (2015); A1;,
Alcohol – Wikipedia,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2240-88-2, name is 3,3,3-Trifluoropropan-1-ol, the common compound, a new synthetic route is introduced below. COA of Formula: C3H5F3O

Tert-butyl [(lr,4r)-6′-bromo-4-methoxy-5″-methyl-3’H-dispiro[cyclohexane-l,2′-indene- ,2″- imidazol]-4″-yl]carbamate (Intermediate 12, 715 mg, 1.50 mmol), allylpalladium(II) chloride (21.95 mg, 0.06 mmol), di-tert-butyl(2′,4′,6′-triisopropyl-3-methoxy-6-methylbiphenyl-2- yl)phosphine (70.3 mg, 0.15 mmol) and CS2CO3 (733 mg, 2.25 mmol) were placed in a MW- vial. Toluene (8 mL) was added and the head space was evacuated and refilled with argon. 3,3,3- Trifluoropropan-l-ol (684 mg, 6.00 mmol) was added and the mixture was heated to 100 C in a MW apparatus for 2 h. 2 M methanolic ammonia (8.57 mL, 60.0 mmol) and water (1.08 mL, 60.0 mmol) was added and the mixture was heated to 80 C for 12 h. The reaction mixture was cooled to r.t. The organic solvents were evaporated and the aqueous residue was extracted with DCM. The combined extracts were concentrated and the residue was purified by reverse phase preparative chromatography providing the title compound (410 mg, 67% yield). 1H MR (500 MHz, DMSO-de) delta 0.90 (td, 1 H), 1.08 – 1.27 (m, 2 H), 1.34 – 1.49 (m, 3 H), 1.80 (d, 2 H), 2.15 (s, 3 H), 2.69 (tt, 2 H), 2.82 – 2.99 (m, 3 H), 3.15 – 3.22 (m, 3 H), 4.00 – 4.10 (m, 2 H), 6.08 (d, 1 H), 6.51 (br. s., 2 H), 6.75 (dd, 1 H), 7.18 (d, 1 H); MS (APCI+) m/z 410 [M+H]+.

The synthetic route of 2240-88-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; KARLSTROeM, Sofia; CSJERNYIK, Gabor; SWAHN, Britt-Marie; SANDBERG, Lars; KOLMODIN, Karin; SOeDERMAN, Peter; OeHBERG, Liselotte; WO2013/190298; (2013); A1;,
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Electric Literature of 4415-82-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 4415-82-1, name is Cyclobutylmethanol. This compound has unique chemical properties. The synthetic route is as follows.

A 50-L jacket vessel was charged with DCM (20 L) (KF 34 ppm), and cyclobutylmethyl alcohol (5.0 kg, 58.0 mol) followed by TEA (8850 mL, 63.5 mol). The reaction mixture was cooled to approximately -10C, and MsCl (4735 mL, 60.8 mol) was added via an addition funnel dropwise over approximately 3 hours, while the temperature was maintained below -5C. The reaction resulted in a yellow slurry after 70 minutes of aging. H20 (8 L) was added to give a clear solution, which was agitated for 15 minutes. Then, the organic layer was separated. H20 (8 L) was charged to the organic layer. The mixture was agitated for 20 minutes, and then the organic layer was separated. Brine (10% solution, 4 L) was charged to the organic layer. The mixture was agitated for 20 minutes, and then the organic layer was separated. The organic phase was concentrated by vacuum distillation at approximately 30C to 40C and 28 inches Hg, resulting in a light brown residue (10.0 kg crude, approximately 9.5 kg product assumed, 58.0 mol, approximately 100% yield). A portion of the material was purified by distillation for characterization.1H NMR (CDC13, 400 MHz): ? 4.18 (d, J = 6.8 Hz, 2H), 3.00 (s, 3H), 2.71 (m, 1H), 2.11 (m, 2H), 2.00-1.80 (m, 4H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 4415-82-1, Cyclobutylmethanol.

Reference:
Patent; MERCK SHARP & DOHME CORP.; WU, George, G.; ITOH, Tetsuji; MCLAUGHLIN, Mark; LIU, Zhijian; QIAN, Gang; WO2013/66734; (2013); A1;,
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Synthetic Route of 100-37-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 100-37-8, name is 2-(Diethylamino)ethanol, molecular formula is C6H15NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

34.9 g (0.1 mol) of 4-[l-(5,6,7,8 -tetrahydro- 3,5,5,8,8-pentamethyl -2-naphthalenyl) ethenyl] benzoic acid (bexarotene, Targretin ) was dissolved in 300 ml of chloroform. 20.6 g of N, N’-Dicyclohexylcarbodiimide was added into the reaction mixture. 11.6 g of dimethylaminoethanol was added into the reaction mixture. The mixture was stirred for 3 hours at RT. The solid was removed by filtration. The chloroform solution was washed with 5% NaHCO (2 x 100 ml) and water (3 x 100 ml). The organic solution was dried over anhydrous sodium sulfate. Sodium sulfate was removed by filtration. 3.6 g of HCl gas in ether (100 ml) was added into the reaction mixture with stirring. The solid product was collected by filtration. After drying, it yielded 40 g of the desired product (85.8%). Hygroscopic product; Elementary analysis: C H ClNO ; MW: 484.11. Calculated % C: 74.43; H: 8.74; Cl:30 42 27.32; N: 2.89; O: 6.61; Found % C: 74.39; H: 8.76; Cl: 7.29; N: 2.91, O: 6.65.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 100-37-8, 2-(Diethylamino)ethanol.

Reference:
Patent; YU, Chongxi; WO2008/87493; (2008); A1;,
Alcohol – Wikipedia,
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Related Products of 616-29-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 616-29-5 as follows.

To a solution of l,3-diaminopropan-2-ol (5 g, 55.48 mmol) in MeOH (50 mL) was added TEA (16.84 g, 166.44 mmol, 23.17 mL) and Boc20 (31.48 g, 144.25 mmol, 33.14 mL) at 15 C. The mixture was stirred at 45C for 12 h under N2atmosphere. The reaction mixture was concentrated under reduced pressure. The residue was purified by column chromatography (silica gel, Petroleum ether/Ethyl acetate=20/l to 0: 1) to give /er/-butyl N-[3-(/er/- butoxycarbonylamino)-2-hydroxy-propyl] carbamate (15.47 g, 96.04% yield) as a white solid.1H NMR (400 MHz, CDCl3): d 5.03 (brs, 2H), 4.08-4.02 (m, 2H), 4.27 (s, 2H), 3.22-3.06 (m, 4H), 1.37 (s, 18H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,616-29-5, its application will become more common.

Reference:
Patent; ARBUTUS BIOPHARMA, INC.; BI, Yingzhi; DORSEY, Bruce D.; FAN, Yi; MOORE, Christopher Brooks; NGUYEN, Duyan; (169 pag.)WO2019/191624; (2019); A1;,
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Adding a certain compound to certain chemical reactions, such as: 124-68-5, 2-Amino-2-methyl-1-propanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: alcohols-buliding-blocks, blongs to alcohols-buliding-blocks compound. category: alcohols-buliding-blocks

To a stirred solution of 2, 4-dichloro-5-methoxypyrimidine (5 g, 27.93 mmol) in 1, 4-dioxane (50 mL) under argon atmosphere were added diisopropylethylamine (7.2 g,55.86 mmol) and 2-amino-2-methylpropan-1-ol (2.4 g, 27.93 mmol) at RT. The reaction mixture was stirred at 130 C for 48 h. After consumption of the starting materials (monitored by TLC), the volatile components were evaporated in vacuo.The residue was diluted with a saturated sodium bicarbonate solution (50 mL) and extracted with EtOAc (2 x 50 mL). The combined organic extracts were dried over sodium sulfate, filtered and concentrated in vacuo. The crude material was purified by column chromatography using 10% EtOAc:hexanes to afford 2-((2-chloro-5 -methoxypyrimidin-4-yl) amino)-2-methylpropan- 1 -ol (5.5 g, 84%) as a white solid. ?H-NMR(DMSO-d6, 500 MHz): oe 7.69 (s, 1H), 6.19 (s, 1H), 6.11 (t, 1H), 3.82 (s, 3H), 3.45 (d, 2H), 1.33 (s, 6H); TLC: 50% EtOAc:hexanes (Rf 0.3).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,124-68-5, 2-Amino-2-methyl-1-propanol, and friends who are interested can also refer to it.

Reference:
Patent; FORUM PHARMACEUTICALS INC.; BURNETT, Duane, A.; BURSAVICH, Matthew, Gregory; MCRINER, Andrew, J.; WO2015/66696; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 2516-33-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2516-33-8, name is Cyclopropylmethanol, molecular formula is C4H8O, molecular weight is 72.1057, as common compound, the synthetic route is as follows.

5-Bromo-2-cyclopropylmethoxy-pyridine 0.49 g (6.82 mmol) cyclopropane methanol in 10 mL THF are charged with 0.42 g (11.4 mmol) NaH and the reaction mixture is stirred at r.t. for 20 min. Then 1.00 g (5.68 mmol) 5-bromo-2-fluoropyridine are added and the mixture is stirred at r.t. over night. The reaction is quenched by the addition of water and extracted with EtOAc. The organic layers are combined, dried over MgSO4, filtered and the solvent is removed in vacuo. The crude product is purified by HPLC (MeOH/H2O/FA). C9H10BrNO (M=228.1 g/mol) ESI-MS: 228/229 [M+H]+Rt(HPLC):1.14 min (method C)

The chemical industry reduces the impact on the environment during synthesis 2516-33-8, I believe this compound will play a more active role in future production and life.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; FLECK, Martin; HEINE, Niklas; NOSSE, Bernd; ROTH, Gerald Juergen; US2014/213568; (2014); A1;,
Alcohol – Wikipedia,
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Application of 5259-98-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 5259-98-3, name is 5-Chloropentan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

Under a nitrogen atmosphere, 7.0 g of a compound represented by the formula (D-9-6)0.7 g of pyridinium p-toluenesulfonate,70 mL of dichloromethane was added.5.8 g of 3,4-dihydro-2H-pyran was added dropwise while cooling with ice, and the mixture was stirred at room temperature for 8 hours.After washing successively with a 5percent aqueous sodium hydrogencarbonate solution and brine,Purification by column chromatography (silica gel, dichloromethane) gave 10.6 g of a compound represented by the formula (D-9-7).

According to the analysis of related databases, 5259-98-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; DIC CORPORATION; HORIGUCHI, MASAHIRO; HAYASHI, MASANAO; (134 pag.)JP2018/70546; (2018); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3597-91-9, name is [1,1′-Biphenyl]-4-ylmethanol, the common compound, a new synthetic route is introduced below. SDS of cas: 3597-91-9

(A) 4-Phenylbenzyl Bromide Triphenylphosphine (1.58 g) and N-bromosuccinimide (1.07 g) were added to a stirred solution of 4-hydroxymethylbiphenyl (1.01 g) in dichloromethane (10 mL) under nitrogen. The mixture was stirred at room temperature for 15 hr and evaporated in vacuo. The residue was diluted with chloroform, and washed with saturated sodium hydrogencarobonate, and brine. The organic layer was dried over anhydrous sodium sulfate and evaporated in vacuo. The residue was purified by silica gel column chromatography (ethyl acetate_hexane=1:100 to 1:50, v/v) to give the titled compound (1.26 g) as colorless crystals: 1H-NMR (400 MHz, CDCl3) delta 4.55 (s, 2H), 7.33-7.38 (m, 1H), 7.41-7.49 (m, 4H), and 7.54-7.60 (m, 4H).

The synthetic route of 3597-91-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Microcide Pharmaceuticals, Inc.; US6399629; (2002); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 149104-89-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 149104-89-2, name is (4-Bromo-3-methylphenyl)methanol, molecular formula is C8H9BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

4-Bromo-3-methylbenzyl methanesulfonate (3)[0302] A solution of compound 2 (2.0 g, 9.95 mmol), Et3N (6.94 mL, 49.7 mmol), and CH2Cl2 (100 mL) was cooled to 0° C. and treated with methanesulfonyl chloride (1.54 mL, 19.9 mmol). The solution was stirred at room temperature for 3 hours. The volatiles were removed under reduced pressure and the resultant crude product was used without further purification.

According to the analysis of related databases, 149104-89-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; CHANG, Christopher J.; VAN DE BITTNER, Genevieve V.; HIRAYAMA, Tasuku; CHAN, Jefferson; US2014/51863; (2014); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts